Xu, Wenqing

Faculty Profile

Submitted by Xu, Wenqing on Fri, 10/08/2010 - 6:24pm

First Name:

Wenqing

Last Name:

Title:

Professor

Primary Institution:

Department/Division:

other

Department/Division:

Biological Structure

E-Mail:

wxu@u.washington.edu

Mail/Box #:

357420

Office Location:

HSB-K452A

Office Phone:

(206) 221-5609

Lab Website:

http://www.biostr.washington.edu/html/xu.html

Research

Research Summary:

We aim to understand how cells sense environment and transduce signals during normal and pathologic conditions, using a combination of structural and biochemical studies. In particular, we are interested in molecular mechanisms of the Wnt signaling pathway and its role in development, stem cell biology and cancer biology. In addition, we are investigating molecular mechanisms of cell regulation by protein phosphorylation and poly-ADP-ribosylation (PARylation). We are also developing small molecule antagonists and/or agonists of protein complexes and enzyme systems, which may be useful for treatment of cancer, osteoporosis and other diseases.

Areas of Interest:

Cell Signaling & Cell/Environment Interactions

Molecular Structure & Computational Biology

Keywords:

<p> X-ray crystallograpgy, signal transduction, structure-based drug design, wnt pathway, cancer, diabetes, Alzheimer's disease, cystic fibrosis, infectious disease, polyphosphate kinase, beta-catenin, Akt</p>

Publications

PubMed Search Term:

xu w seattle

Search

Xu, Wenqing

Faculty Profile

Related content