Xu, Wenqing

Faculty Profile

First Name: 
Wenqing
Last Name: 
Xu
[field_fname-formatted] [field_lname-formatted]
Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Biological Structure
Mail/Box #: 

357420

Office Location: 

HSB-K452A/F530

Office Phone: 
(206) 221-5609
Alternate Phone: 
(206) 221-2435
Research

Research Summary: 

We aim to understand how cells sense environment and transduce signals during normal and pathologic conditions, using a combination of structural and biochemical approaches. In particular, we are interested in molecular mechanisms of the Wnt signaling pathway, which plays critical roles in embryonic development, adult tissue homeostasis and tumorigenesis. We are also investigating how proteins or protein assemblies control cell activities via protein phosphorylation and poly-ADP-ribosylation (PARylation). Furthermore, we strive to develop small molecule antagonists and/or agonists of key protein complexes and enzymes, which can be used as chemical probes for important cellular processes and may be therapeutically useful for treatment of cancer, osteoporosis and other diseases.

Short Research Description: 
Structural biology of cell regulation
Areas of Interest: 
Molecular Structure & Computational Biology
Keywords: 
<p> X-ray crystallograpgy, signal transduction, structure-based drug design, protein design, Wnt signaling pathway, cancer, stem cell, diabetes, protein kinase and phosphatase, beta-catenin, protein poly(ADP-ribosy)lation (PARylation), tuberous sclerosis complex (TSC).</p>
Publications

Taking Students
Year: 
2013 - 2014

Related content

Student Profile
Course