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WELCOME TO THE ATKINS LAB
NEWS
Caleb Woods was awarded a National ACS Division of Medicinal Chemistry
Fellowship, for his studies on Allosteric effects on N-dealkylation reactions
by Cytochrome P450 3A4. The award includes support to attend the ACS meeting
in Boston next spring.
Doug Lu, currently doing a Post Doc at UCSD, was recently awarded an
NIH-NIDA NRSA Fellowship for a project titled "Proenkephalin Processing
for Biosynthesis of Enkephalin Peptide Neurotransmitter."
Larissa Balogh recently defended her thesis titled "Stereochemical
Complexities in the Glutathione S-Transferase Catalyzed Detoxification
of 4-Hydroxynonenal." Her work included stereochemical analysis of the
metabolism of HNE by GSTs, and she has solved, in collaboration with the
Stenkamp lab in Biochemistry, the crystal structures of key GST mutants
to understand the structural basis of the stereoselectivity.
Art Roberts, who championed the NMR efforts in our lab, has taken a
position on the faculty at the Skaggs School of Pharmacy at University of
California San Diego. Art started his new position in January 2009. We
wish him the best of luck.
Abhinav Nath defended his thesis in October 2008. He has started a
postdoctoral position in the lab of Dr. Liz Rhoades in the Department of
Molecular Biophysics and Biochemistry at Yale University. We look forward to
continuing our collaboration with Abhi and the Rhoades lab to use single
molecule spectroscopy methods. Abhi has recently been awarded a Yale University postdoctoral fellowship.
Dr. Atkins presented the Lab's latest data on the use of biophysical
methods to understand CYP allostery at the 16th International Conference
on Cytochrome P450s in Nagano, Japan in June 2009.
RESEARCH INTERESTS
TECHNIQUES AND INSTRUMENTS
We use a wide variety of spectroscopic and analytical techniques
in the course of our research. We own a Fluorolog Tau-3 frequency-domain
instrument for time-resolved fluorimetry, as well as two SLM/Aminco steady-state
fluorimeters (an AB-2 and an 8100) and an Applied Photophysics
SX.18MV-R for stopped-flow fluorescence and absorbance measurements. We
also own two Waters HPLC systems for analytical and preparative purposes.
We share a number of instruments with the rest of the Medicinal Chemistry Department,
including a Varian 500 MHz Unity Inova NMR, absorbance spectrophotometers (an
Olis Modernized Aminco DW-2 and a Cary 3E), and facilities for protein
expression in bacterial and insect-cell systems.
We have access to several mass spectrometry instruments via the Department's
Mass Spectrometry
Center, as well as several additional NMR instruments (a 750 MHz, a 500 MHz,
and two 300 MHz) via the
Dept. of Chemistry NMR facility. For surface plasmon resonance experiments, we use a
Biacore 2000 in the Dept. of Phyysiology & Biophysics, and we also have access
to nanoscale characterization and fabrication tools (atomic force microscopy, electron
microscopy and confocal fluorescence microscopy) at the
Nanotech User Facility and
the Dept. of Pathology
EM Center.
USEFUL LINKS
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