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ACADEMIC BIO
B.S. in Chemistry, The College of William and Mary, 1980.
M.A. in Pharmacology, Harvard University, 1983.
Ph.D. in Biochemistry, The University of Illinois, 1989.
Postdoctoral Studies in Protein Dynamics, Penn State University, 1988-1991.
RESEARCH OVERVIEW
Our lab studies enzymes and proteins that participate
in the detoxification of foreign chemicals, including therapeutic drugs. We are
fascinated by enzymes that can metabolize many structurally unrelated substrates,
because this behavior defies "traditional" views of enzymology. We are
also studying therapeutic antibodies and other pharmaceutically important
proteins, to understand structure-function aspects of their tissue targeting,
clearance, and in vitro stability. Taken together, these research areas provide
a wide-ranging blend of methodologies and experimental approaches that train
undergraduates, graduate students, and post-doctoral fellows for careers in
biotechnology, the pharmaceutical industry, and related areas of academic
research. We utilize a diverse array of biophysical, chemical, and biological
approaches, to understand these enzymes and proteins in the context of systems
biology. Our lab values broad training and collaborative research. Students
are encouraged to indentify and learn the methods that best illuminate their
specific projects, rather than rely solely on methods established by other lab members.
SPECIFIC PROJECTS
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