Department of Medicinal Chemistry - Current Research

Our Latest Publications

Hengel SM, Shaffer SA, Nunn BL, Goodlett DR. "Tandem mass spectrometry investigation of ADP-ribosylated kemptide." J Am Soc Mass Spectrom. 2009 Mar; 20(3):477-83.

Malmstroem L, Hou L, Atkins WM, Goodlett DR. "On the use of hydrogen/deuterium exchange mass spectrometry data to improve de novo protein structure prediction." Rapid Commun Mass Spectrom. 2009 Feb; 23(3):459-61.

McDonald MG, Rieder MJ, Nakano M, Hsia CH, Rettie AE. "CYP4F2 is a Vitamin K1 Oxidase: An Explanation for Altered Warfarin Dose in Carriers of the V433M Variant." Mol Pharmacol. 2009 Mar 18 [Epub ahead of print].

Yang Q, Maluf NK, Catalano CE. "Packaging of a unit-length viral genome: the role of nucleotides and the gpD decoration protein in stable nucleocapsid assembly in bacteriophage lambda." J Mol Biol. 2008 Nov 28; 383(5):1037-48.

Mosher CM, Hummel MA, Tracy TS, Rettie AE. "Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9." Biochemistry 2008 Nov 11; 47(45):11725-34.

Nath A, Koo PK, Rhoades E, Atkins WM. "Allosteric effects on substrate dissociation from cytochrome P450 3A4 in nanodiscs observed by ensemble and single-molecule fluorescence spectroscopy." J Am Chem Soc. 2008 Nov 26; 130(47):15746-7.

Wen B, Coe KJ, Rademacher P, Fitch WL, Monshouwer M, Nelson SD. "Comparison of in Vitro Bioactivation of Flutamide and its Cyano Analogue: Evidence for Reductive Activation by Human NADPH:Cytochrome P450 Reductase. Chem Res Toxicol. 2008 Nov 4 [Epub ahead of print].

Balogh LM, Roberts AG, Shireman LM, Greene RJ, Atkins WM. "The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases." J Biol Chem. 2008 Jun 13; 283(24):16702-10.

Templeton IE, Thummel KE, Kharasch ED, Kunze KL, Hoffer C, Nelson WL, Isoherranen N. "Contribution of itraconazole matabolites to inhibition of CYP3A4 in vivo." Clin Pharmacol Ther. 2008 Jan; 83(1):77-85.

Gao Q, Xue S, Shaffer SA, Doneanu CE, Goodlett DR, Nelson SD. "Minimize the detection of false positives by the software program DetectShift for 18O-labeled cross-linked peptide analysis." Eur J Mass Spectrom. (Chichester, Eng). 2008; 14(5):275-80.