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Department of Medicinal Chemistry - Current Research
What's New?
Dr. Rheem Totah has been invited to present her work on arachidonic acid
metabolism by CYP2J2 and cardiotoxicity at the Drug Metabolism Gordon Research
Conference to be held July 6-11, 2008 at Holderness School Holderness, NH.
Our Latest Publications
Scherl A, Shaffer SA, Taylor GK, Kulasekara HD, Miller SI, Goodlett DR.
Genome-Specific Gas-Phase Fractionation Strategy for Improved Shotgun Proteomic Profiling of Proteotypic Peptides.
Anal Chem. 2008 Jan 23; [Epub ahead of print]
Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L.
Genetic basis of proteome variation in yeast.
Nat Genet. 2007 Nov;39(11):1369-75. Epub 2007 Oct 21.
Wang H, Kennedy DS, Nugent KD, Taylor GK, Goodlett DR.
A Qit-q-Tof mass spectrometer for two-dimensional tandem mass spectrometry.
Rapid Commun Mass Spectrom. 2007;21(19):3223-6.
Lampe JN, Fernandez C, Nath A, Atkins WM.
Nile Red is a fluorescent allosteric substrate of cytochrome P450 3A4.
Biochemistry. 2008 Jan 15;47(2):509-16. Epub 2007 Dec 20.
Nath A, Atkins WM.
A quantitative index of substrate promiscuity.
Biochemistry. 2008 Jan 8;47(1):157-66. Epub 2007 Dec 15.
Nath A, Grinkova YV, Sligar SG, Atkins WM.
Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs: the effect of model membranes.
J Biol Chem. 2007 Sep 28;282(39):28309-20. Epub 2007 Jun 15.
Wen B, Ma L, Nelson SD, Zhu M.
High-Throughput Screening and Characterization of Reactive Metabolites Using Polarity Switching of Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry.
Anal Chem. 2008 Feb 6; [Epub ahead of print]
Harrelson JP, Atkins WM, Nelson SD.
Multiple-Ligand Binding in CYP2A6: Probing Mechanisms of Cytochrome P450 Cooperativity by Assessing Substrate Dynamics.
Biochemistry. 2008 Feb 5; [Epub ahead of print]
Kostrubsky SE, Strom SC, Ellis E, Nelson SD, Mutlib AE.
Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
Chem Res Toxicol. 2007 Oct;20(10):1503-12. Epub 2007 Sep 28.
McDonald MG, Rettie AE.
Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol intermediate.
Chem Res Toxicol. 2007 Dec;20(12):1833-42. Epub 2007 Nov 20.
Rieder MJ, Reiner AP, Rettie AE.
Gamma-glutamyl carboxylase (GGCX) tagSNPs have limited utility for predicting warfarin maintenance dose.
J Thromb Haemost. 2007 Nov;5(11):2227-34. Epub 2007 Aug 22.
Baer BR, Kunze KL, Rettie AE.
Mechanism of formation of the ester linkage between heme and Glu310 of CYP4B1: 18O protein labeling studies.
Biochemistry. 2007 Oct 16;46(41):11598-605. Epub 2007 Sep 19.
Templeton IE, Thummel KE, Kharasch ED, Kunze KL, Hoffer C, Nelson WL, Isoherranen N.
Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.
Clin Pharmacol Ther. 2008 Jan;83(1):77-85. Epub 2007 May 9.
Zhao P, Lee CA, Kunze KL.
Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A.
Drug Metab Dispos. 2007 May;35(5):704-12. Epub 2007 Feb 9.
Ortega ME, Gaussier H, Catalano CE.
The DNA maturation domain of gpA, the DNA packaging motor protein of bacteriophage lambda, contains an ATPase site associated with endonuclease activity.
J Mol Biol. 2007 Nov 2;373(4):851-65. Epub 2007 Aug 14.
Maluf NK, Gaussier H, Bogner E, Feiss M, Catalano CE.
Assembly of bacteriophage lambda terminase into a viral DNA maturation and packaging machine.
Biochemistry. 2006 Dec 26;45(51):15259-68. Epub 2006 Nov 30.
PMID: 17176048 [PubMed - indexed for MEDLINE]
Khrapunov S, Brenowitz M, Rice PA, Catalano CE.
Binding then bending: a mechanism for wrapping DNA.
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19217-8. Epub 2006 Dec 11.
Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED.
Enantiomeric metabolic interactions and stereoselective human methadone metabolism.
J Pharmacol Exp Ther. 2007 Apr;321(1):389-99. Epub 2007 Jan 26.
Gaedigk A, Baker DW, Totah RA, Gaedigk R, Pearce RE, Vyhlidal CA, Zeldin DC, Leeder JS.
Variability of CYP2J2 expression in human fetal tissues.
J Pharmacol Exp Ther. 2006 Nov;319(2):523-32. Epub 2006 Jul 25.
Elmer GW, Lafferty WE, Tyree PT, Lind BK.
Potential interactions between complementary/alternative products and
conventional medicines in a Medicare population.
Ann Pharmacother. 2007 Oct;41(10):1617-24. Epub 2007 Sep 4.
Taibi DM, Vitiello MV, Barsness S, Anderson GD, Elmer GW, Landis CA.
A randomized clinical trial of valerian fails to improve subjective and
objecctive sleep quality of older women with sleep distrubance.
Sleep Med. in press.
Ongoing Research
For a more detailed description of ongoing research by faculty, including full
journal article listings, see the Faculty page.
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