Medicinal Chemistry Seminar

Meets Mondays from 4:00 - 5:00 PM in H-074.
NOTE: Email your papers in advance to Caryl Lynch for posting to the web site.

Monday Night Meeting (MedCh 582)
Schedule

Autumn 2009

Date	Speaker	Paper (Click title to download PDF)	Questions for Discussion
10/05/09	No MNM	No meeting
10/12/09	Matt Honaker	Exploring the Electron Transfer Properties of Neuronal Nitric-oxide Synthase by Reversal of the FMN Redox Potential (PDF)	Supplemental Discussion (PDF)
10/19/09	Kelsey Hanson	Effect of Intestinal Glucuronidation in Limiting Hepatic Exposure and Bioactivation of Raloxifene in Humans and Rats (PDF)
10/26/09	Brendan Stamper	The Mitochondrial Superoxide/Thioredoxin-2/Ask1 Signaling Pathway is Critically Involved in Troglitazone-Induced Cell Injury to Human Hepatocytes (PDF)
11/2/09	Oliver Parkinson	Simultaneous Expression of Plural Forms of Human Cytochrome P450 at Desired Ratios in HepG2 Cells: Adenovirus- mediated Tool for Cytochrome P450 Reconstitution (PDF)
11/9/09	Peter Rademacher	Selective Oxidation of Carbolide C-H Bonds by an Engineered Macrolide P450 Mono-oxygenase (PDF)	Supporting Information (PDF)
11/16/09	Kayte Zumberge	Benzylic Oxidation of Gemfibrozil-1-Ο-Β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition (PDF)
11/23/09	No MNM	No meeting
11/30/09	Pragya Singh	The Potential of Desferrioxamine-Gallium as an Anti-Pseudomonas Therapeutic Agent (PDF)
12/7/09	Elizabeth Medina

Spring 2009

Date	Speaker	Paper (Click title to download PDF)	Questions for Discussion
03/30/09	Caleb Woods	Kinetic Isotope Effects in Hydroxylation Reactions Effected by Cytochrome P450 Compounds I Implicate Multiple Electrophilic Oxidants for P450-Catalyzed Oxidations	Caleb's Questions (DOC) or (PDF)
04/06/09	Kayte Zumberge	Irreversible Inhibition of the Myobacterium tuberculosis β-Lactamase by Clavulanate
04/13/09	Michelle Wahlin	Dehydrogenation of Indoline by Cytochrome P450 Enzymes: A Novel "Aromatase" Process
04/20/09	Rishi Sanyal	Liver-Targeted Prodrugs of 2‘-C- Methyladenosine for Therapy of Hepatitis C Virus Infection
04/27/09	Trisha Zhao	Biotransformation of 3-Amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin- 4(3H)-one (TZB-30878), a Novel 5-Hydroxytryptamine (5-HT)_1A Agonist/5-HT₃ Antagonist, in Human Hepatic Cytochrome P450 Enzymes
05/04/09	Kip Conner	In Vitro Metabolism and Covalent Binding of Enol-Carboxamide Derivatives and Anti-Inflammatory Agents Sudoxicam and Meloxicam: Insights into the Hepatotoxicity of Sudoxicam
05/11/09	Mimi Nguyen	Potent and Highly Selective Hypoxia-Activated Achiral Phosphoramidate Mustards as Anticancer Drugs
05/18/09	Laura Shireman	Cancelled
05/25/09	HOLIDAY
06/01/09	Rotation Talks (John Chapman, Jon Katayama, Eri Nakatani)	TBA

Winter 2009

Date	Speaker	Paper (Click title to download PDF)
01/12/09	No MNM
01/19/09	HOLIDAY
01/26/09	Brooke Vandenbrink	Mode of Inhibition of ß-Hydroxydecanoyl Thioester Dehydrase by 3-Decynoyl-N-acetylcysteamine
02/02/09	Brendan Stamper	The Fate of Acetanilide in Man
02/09/09	Tasha Ritchie	Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis
02/16/09	HOLIDAY
02/23/09	Shawna Hengel	A Putative Role for Nicotinamide Adenine Dinucleotide-promoted Nuclear Protein Modification in the Antitumor Activity of N-Methyl-N-nitrosourea
03/02/09	Clara Hsia	Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage
03/09/09	Mariko Nakano	Expression and enzymatic activity of recombinant cytochrome P450 17α-hydroxylase in Escherichia coli
03/16-20	EXAMS WEEK

For questions and comments concerning our department see "Contact Us."
For questions and comments concerning these web pages, email the Webmaster.