University of Washington
1100 Fairview Ave N, Room C2-105
FHCRC, Box 358080
Seattle, WA 98109-1024
Phone: (206) 667-2890
Phone: (206) 667-2855
FAX: (206) 667-6523
Research: Advances in molecular biology have made it feasible to cure genetic disease by transfer of corrective genes to somatic tissues of humans. Dr. Miller has focused on the development of viral vectors derived from retroviruses and adeno-associated virus, and has demonstrated gene transfer and expression in many somatic cell types in culture and in animals. These vectors have been used in many gene transfer trials in humans, but much development work remains to make gene therapy an effective treatment. Other ongoing studies focus on the basic biology and properties of adeno-associated virus vectors and their potential for use in gene therapy, and on retrovirus biology, including the nature of the receptors used for entry of retroviruses into cells and the evolution of the retrovirus envelope proteins that interact with these receptors.
Investigator: Dr. Miller is a Member of the Divisions of Human Biology and Basic Sciences of the Fred Hutchinson Cancer Research Center. He is an Affiliate Professor of Pathology at the University of Washington.