André M. Lieber, M.D., Ph.D.

Professor of Medicine, Adjunct Professor of Pathology

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University of Washington
K-240B Health Sciences Building
Medical Genetics, Box 357720
Seattle, WA 98195-7720

Phone: (206) 221-3973
Phone: (206) 543-0109
FAX: (206) 685-8675
E-mail: lieber00@u.washington.edu




Research Program:

Cancer gene therapy

  • Ovarian cancer stem cells
  • Mechanisms of tumor resistance
  • Oncolytic adenoviruses for tumor gene therapy, phase I trial for metastatic cancer
  • Immuno-gene therapy of cancer
Stem cell gene therapy
  • Retargeted adenoviruses with tropism for bone-marrow derived stem cells
  • Adenovirus vector integration into the genome of stem cells through chromatin tethering
  • Site-specific integrating Adeno-AAV hybrid vectors for ex vivo stem cell gene therapy
Molecular adenovirology
  • New adenovirus receptors
  • Determinants for in vivo tropism of adenoviruses
  • Cell signaling induced by adenovirus infection



Representative Publications:

Wang H, Liaw YC, Stone D, Kalyuzhniy O, Amiraslanov I, Tuve S, Verlinde CL, Shayakhmetov D, Stehle T, Roffler S, Lieber A. (2007) Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob. Journal of Virology, 2007 Sep 26; [Epub ahead of print]

Tuve S., Chen, B-M., Liu, Y., Cheng, T-L, Touré, P., Sow, p.S., Feng, Q., Kiviat, N., Ni, S., Li, ZY., Roffler, S.R., Lieber, A. (2007) Combination of tumor-site located CTLA-4 blockade and systemic Treg depletion induces anti-tumor immunity but not autoimmunity. Cancer Research, 67: 5929-5939

Wang, H-J., Leege, T., Shayakhmetov, D., Li, Q., Papayannopoulou, T., Stamatoyannopolous, G., Lieber, A. (2005) A capsid-modified helper-dependent adenovirus vector containing the beta-globin locus control region displays a non-random integration pattern and allows for stable, erythroid-specific gene expression. Journal of Virology, 79: 10999-1013

Sova, P. Ren, X-W., Ni, S. Bernt, K., Mi, J., Kiviat, N., Lieber, A. (2004) A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. Molecular Therapy, 9: 496-509

Gaggar, A., Shayakhmetov, D.M., Lieber, A. (2003) CD46 is a cellular receptor for group B adenovirus. Nature Medicine, 9: 1408-12

Steinwaerder, D.S., Carlson, C.A., Otto, D.L., Li, Z-Y., Ni, S., Lieber, A. (2001) Tumor specific gene expression in hepatic metastases by a replication-activated adenovirus vector. Nature Medicine, 7: 2140-243