Dr. Browning's research is focused on the development of statistical and computational methods for analysis of large-scale genetic data from microarray genotyping and next-generation sequencing. These genetic data sets present computational and analytical challenges due to their size (which can exceed 40 billion data points), and due to the complex patterns of inter-marker correlation in the data. Carefully engineered algorithms and software are necessary to extract the full information from these rich data sets.
BEAGLE - genotype imputation, haplotypic testing, and haplotype phase inference for unrelated individuals and parent-offspring trios.
BEAGLE Utilities - a collection of utility programs for manipulating large data files.
BEAGLECALL - genotype calling using linkage disequilibrium for unrelated individuals.
PRESTO - fast computation of order statistic distributions and multiple testing adjusted p-values for genome-wide association studies.
FLOSS - ordered subset linkage analysis.