Phillip F. Chance, M.D.

Professor of Neurology and Pediatrics
Chief of Division of Genetics & Development

University of Washington
RR-247 Health Sciences Building
Pediatrics, Box 356320
Seattle, WA 98195

Phone: (206) 616-3787
Phone: (206) 526-2058
FAX: (206) 543-3184

Research Program:

Dr. Chance has established a laboratory with an interest in the molecular basis of inherited neurologic disorders, especially diseases of peripheral nerves including various forms of Charcot-Marie-Tooth neuropathy and amyotrophic lateral sclerosis (ALS; also called Lou Gehrig's disease). Through work in Dr. Chance's laboratory the chromosomal location or molecular basis of several different peripheral nerve disorders has been defined. The observations have advanced the genetic nosology within peripheral nerve diseases, have immediate relevance to the practice of clinical medicine and may provide a critical prelude to the development of rational therapies for patients. Dr. Chance's current projects include positional cloning of the genes for inherited brachial plexus neuropathy and for a juvenile-onset form of ALS. Other current projects in Dr. Chance's lab focus on the identification of genetic abnormalities in malformation syndromes affecting the cerebellum and an analysis of the structure and ontogeny of a transposon-associated repeat sequence on the short arm of chromosome 17.

Representative Publications: