University of Washington
J-211 Health Sciences Building
Genetics, Box 357360
Seattle, WA 98195
Phone: (206) 543-4001
FAX: (206) 543-0754
Dr. Deeb’s group is presently involved in two major projects:
1) The molecular genetics of red/green color vision. A high degree of variation in the ability to discriminate between colors in the middle-to-long wavelengths has been observed in the general population. This phenotypic variation was observed among individuals who are classified as either color vision defective or normal. Dr. Deeb and colleagues have determined the molecular basis for the two major phenotypic classes among individuals with normal color vision to be a single amino acid polymorphism in the red pigment gene. A partial understanding of the molecular basis of the various classes and severity of color vision deficiency was achieved by gross analysis of the red/green pigment gene assays.
2) The molecular basis of dyslipoproteinemia. Dr. Deeb’s laboratory is investigating variants of candidate genes involved in plasma lipoprotein metabolism that may be associated with elevated low density or diminished high density lipoprotein levels. Apolipoproteins A-I and B-1000 and the enzyme lipoprotein lipase are the main candidates being investigated using techniques of linkage analysis and DNA sequence determination. In addition, cis-regulatory elements of the lipoprotein lipase gene are being extensively studied by introduction of various regulatory regions driving the expression of Lac Z into cell lines and transgenic mice.