Virginia P. Sybert, M.D.

Clinical Professor, Division of Medical Genetics,
Department of Medicine, University of Washington
Staff Physician, Dermatology, Group Health Permanente

University of Washington
Medicine/Medical Genetics
Box 357720
Seattle, WA 98195-7720
Physical location: CHDD 411

Phone: (206) 598-4030
FAX: (206) 598-3269

University of Washington
Appointments: 206-598-4030

Group Health Permanente
Dermatology Appointment Line: 206-326-2111
Dermatology Office Number (backline): 206-326-2257
Dermatology FAX: 206-326-2110

If you need immediate help with UW patient care matters, please call the Medical Genetics Office at 206-598-4030, as appropriate.

Research Program:

Dr. Sybert is a clinical geneticist pursuing two major areas of research. The first is a long-term study of the sex chromosome disorder, Turner syndrome. She has established a large (550 patients) clinic for children and adults with Turner syndrome. Through this clinic, she has investigated several aspects of the natural history of Turner syndrome. Current projects include recommendations for care, description of long-term complications, cardiovascular complications. and evaluation of psychosexual and self-image attitudes in adults with Turner Syndrome.

The second general area of research is in the inherited disorders of the skin: neurofibromatosis (she and Dr. Karen Stephens have a long-standing collaboration); disorders of keratinization; the blistering conditions (epidermolysis bullosa) and the ectodermal dysplasias.

She is the author of Genetic Skin Disorders (Oxford University Press, 1997), winner of the Clinical Medicine Award. Association of American Publishers and has been listed in Best Doctors in America in both Medical Genetics and Dermatology since 1994.

Investigator: Dr. Sybert is a Professor of Medicine (Medical Genetics) and a Staff Physician (Dermatology) at Group Health Cooperative in Seattle.

Representative Publications:

Mitchell A, Parisi M, Sybert VP. Effects of pregnancy on the renal and pulmonary manifestations in women with tuberous Sclerosis complex. Genet Med 5(3):154-60, 2003.

Sybert VP. Ectodermal dyplasias. In Fitzpatrick's Dermatology in General Medicine. 6th edition. I Freedberg et al (eds). New York: McGraw-Hill, 2003.

Sybert VP and Zonana J. Ectodermal dyplasias. In Dermatology. J Bolognia et al (eds). New York: Mosby, 2003.

Sybert VP. Turner syndrome. In Management of Genetic Disorders. Cassidy S and Allanson J (eds) New York: Wiley-Liss, 2003.

Leppig KA, Sybert VP, Ross JL, Cunniff C, Trejo T, Raskind WH, Disteche CM. Phenotype and X inactivation in 45,X/46,X,r(X) cases. Am J Med Genet A. 2004 Jul 30;128(3):276-84.

Sybert VP, McCauley E. Turner's syndrome. N Engl J Med. 2004 Sep 16;351(12):1227-38. Review. No abstract available.

Kelsell DP, Norgett EE, Unsworth H, Teh MT, Cullup T, Mein CA, Dopping-Hepenstal PJ, Dale BA, Tadini G, Fleckman P, Stephens KG, Sybert VP, Mallory SB, North BV, Witt DR, Sprecher E, Taylor AE, Ilchyshyn A, Kennedy CT, Goodyear H, Moss C, Paige D, Harper JI, Young BD, Leigh IM, Eady RA, O'Toole EA. Free in PMC Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis. Am J Hum Genet. 2005 May;76(5):794-803.

Siegel DH, Sybert VP. Understanding aneuploidy. Pediatr Dermatol. 2005 May-Jun;22(3):270-5.

Lombillo VA, Sybert VP. Mosaicism in cutaneous pigmentation. Curr Opin Pediatr. 2005 Aug;17(4):494-500. Review.

Motil KJ, Fete TJ, Fraley JK, Schultz RJ, Foy TM, Ochs U, Sybert VP. Growth characteristics of children with ectodermal dysplasia syndromes. Pediatrics. 2005 Aug;116(2):e229-34.

Siegfried E, Bree A, Fete M, Sybert VP. Skin erosions and wound healing in ankyloblepharon-ectodermal defect-cleft lip and/or palate. Arch Dermatol. 2005 Dec;141(12):1591-4.

Chien AJ, Valentine MC, Sybert VP. Hereditary woolly hair and keratosis pilaris. J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S35-9.

Siegel DH, Sybert VP. Mosaicism in genetic skin disorders. Pediatr Dermatol. 2006 Jan-Feb;23(1):87-92.