Wylie Burke, M.D., Ph.D.


Professor and Chair, Department of Bioethics and Humanities
Adjunct Professor of Medicine (Medical Genetics) and Epidemiology
Member of the Fred Hutchinson Cancer Research Center

University of Washington
1959 NE Pacific, Room A204
Box 357120
Seattle, WA 98195

Phone:(206) 221-5482
Fax: (206) 685-7515
E-mail: wburke@u.washington.edu

Research Program:

Wylie Burke is Professor and Chair of the Department of Bioethics and Humanities at the University of Washington (UW). She received a PhD in Genetics (1974) and an MD (1978) from UW, completed a medical residency in Internal Medicine (1981) and was as a Medical Genetics Fellow (1981-2) at UW. She is an Adjunct Professor in the Departments of Medicine and Epidemiology and a Member of the Fred Hutchinson Cancer Research Center, and is a member of the Institute of Medicine and the Association of American Physicians. She served on the Secretary’s Advisory Committee on Genetic Testing (1999-2002) and the National Human Genome Advisory Council (1999-2003), and was President of the American Society of Human Genetics in 2007.

Dr. Burke is Principal Investigator of the University of Washington Center for Genomics and Healthcare Equality, an NIH Center of Excellence in Ethical, Legal and Social Implications (ELSI) Research . The center promotes interdisciplinary work addresses the ethical and policy implications of genetic information in research, medicine and public health, with an emphasis on the implications of genomics for medically underserved populations. It also maintains a training programs offering research experiences at the undergraduate and graduate levels, with outreach and partnerships with American Indian and Alaska Native communities.

Representative Publications:

Burke W, Pinsky L, Press N. Categorizing genetic tests to identify their ethical, legal and social implications. Am J Med Genet (Semin Med Genet) 2001; 106;233-240.

Burke W. Genetic testing. New Eng J Med 2002; 347: 1967-1975.

Haga S, Khoury M, Burke W. Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nature Genet 2003; 34: 347-350.

Beskow L,M, Botkin JR, Daly M, Juengst ET, Lehmann LS, Merz JF, Pentz R, Press NA, Ross LF, Sugarman J, Susswein LR, Terry SF, Austin MA, Burke W. Ethical issues in identifying and recruiting participants for familial genetic research. Am J Med Genet 2004; 130A: 424-431.

Press N, Reynolds S, Pinsky L, Murthy V, Leo M, Burke W. ‘That’s like chopping off a finger because you’re afraid it might get broken’: disease and illness in women’s views of prophylactic mastectomy. Soc Sci Med 2005; 61:1106-1117.

Burke W, Press N. Genetics as a tool to improve cancer outcomes: ethics and policy. Nat Rev Cancer 2006; 6:476-82.

Burke W, Kroese M, Zimmern R. Defining purpose: a key step in genetic test evaluation. Genet Med 2007;9: 675-81.

Burke W, Psaty BM. Personalized medicine in the era of genomics. JAMA 2007;298:1682-4.

Henriksen N, Burke W, Veenstra D. Ancillary risk information and pharmacogenetic tests: social and policy implications. Pharmacogenomics J. 2008 8: 85-89.

Shields AE, Burke W, Levy DE. The use of available genetic tests among minority-serving physicians in the US. Genet Med. 2008 Jun;10:404-14. [PMC2764316]

Haga S, Burke W. Pharmacogenetic testing: not as simple as it seems. Genet Med. 2008;10:391-5.

McGuire AL, Burke W. An unwelcome side effect of direct to consumer personal genome testing: raiding the medical commons. JAMA 2008;300:2669-71.

Tarini B, Burke W, Scott CR, Wilfond B. Waiving informed consent in newborn screening research: balancing social value and respect. Am J Med Genet 2008 Feb 15;148C:23-30.

Burke W, Culver J, Pinsky L, Hall S, Reynolds SE, Yasui Y, Press N. Genetic assessment of breast cancer risk in primary care practice. Am J Med Genet 2009; Part A 149A;349-56.

Laberge A-M. Hindorff LA, Psaty BM, Burke W. Use of Factor V Leiden genetic testing in practice and impact on management. Genet Med. 2009 Oct;11(10):750-6.

Burke W, Laberge A-M, Press N. Debating clinical utility. Public Health Genom 2010; 13(4):215-23.

Trinidad SB, Fullerton SM, Bares JM, Jarvik GP, Larson EB, Burke W. Genomic research and wide data sharing: views of prospective participants. Genet Med, in press.