David Emery, Ph.D.Research Associate Professor of Medicine K-236F Health Sciences Building |
Research in the Emery laboratory is focused on basic and translational research in the field of hematopoietic stem cell gene therapy. One major area of interest involves the development of recombinant virus vectors for therapeutic globin genes and the testing of these vectors in mouse and non-human primate models. This includes in part the use of transgenic mouse models of beta-thalassemia intermedia and beta-thalassemia major to study the transfer, expression, and biological function of candidate vectors. Another major area of interest includes the identification, characterization, and application of chromatin insulators in order to improve the efficacy and safety of recombinant virus vectors. This includes in part the use of genetic screens and informatics to identify potential insulators, the study of insulator activity on chromatin structure, and the development of novel tumor formation assays to study vector-related genotoxicity
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