Dr. Hua Cao is a molecular haematologist who has done groundbreaking research in developing a new class of therapeutics which stimulate production of fetal haemoglobin. Dr. Hua Cao’s research interests include: 1) investigations of the effects of new synthetic histone deacetylase inhibitors on gamma globin gene transcription using in vitro and ex vivo systems; 2) investigation of such inhibitors in transgenic mice; 3) performance of pre-clinical studies of selected HDAC inhibitors in primates; and 4) investigating, using molecular biology technology, of the mechanism of activation of gamma genes by inhibitors of histone deacetylase.

Representative Publications:

Evangelia Skarpidi, Hua Cao, Brian F. White, Ronald L. Marhenke, Manfred Jung and George Stamatoyannopoulos. Hydroxamide derivatives Of short-Chain fatty acids are potent inducers of fetal hemoglobin production. Exp Hematol. 2003, 31:197-203.

Hua Cao, Manfred Jung, George Stamatoyannopoulos. Induction of gamma gene expression by amide analogues of Trichostatin A. Blood. 2004, 15;103(2):701-9.

Hua Cao. Pharmacological induction of fetal hemoglobin synthesis using histone deacetylase inhibitors. Hematology. 2004, 9(3):223-33.

Hua Cao, Manfred Jung, George Stamatoyannopoulos. Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo. Exp Hematol. 2005, 33: 1443-1449.

Tamon Nishino, Hua Cao, George Stamatoyannopoulos and David W. Emery. Effects of human gamma-globin in murine beta-thalassaemia. Br J Haematol. 2006 , 134(1):100-8.

Hua Cao, George Stamatoyannopoulos. Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin. Am J Hematol. 2006, 81(12): 981-983.

Investigator: Dr. Cao is an Acting Instructor in the Division of Medical Genetics.

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