Research Professor of Medicine,
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Research topics:
Cancer gene therapy
- Ovarian cancer stem cells
- Mechanisms of tumor resistance
- Oncolytic adenoviruses for tumor gene therapy, phase I trial for metastatic cancer
- Immuno-gene therapy of cancer
Stem cell gene therapy
- Retargeted adenoviruses with tropism for bone-marrow derived stem cells
- Adenovirus vector integration into the genome of stem cells through chromatin tethering
- Site-specific integrating Adeno-AAV hybrid vectors for ex vivo stem cell gene therapy
Molecular adenovirology
- New adenovirus receptors
- Determinants for in vivo tropism of adenoviruses
- Cell signaling induced by adenovirus infection
Selected publications:
Wang H, Liaw YC, Stone D, Kalyuzhniy O, Amiraslanov I, Tuve S, Verlinde CL, Shayakhmetov D, Stehle T, Roffler S, Lieber A. (2007) Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob. Journal of Virology, 2007 Sep 26; [Epub ahead of print]
Tuve S., Chen, B-M., Liu, Y., Cheng, T-L, Touré, P., Sow, p.S., Feng, Q., Kiviat, N., Ni, S., Li, ZY., Roffler, S.R., Lieber, A. (2007) Combination of tumor-site located CTLA-4 blockade and systemic Treg depletion induces anti-tumor immunity but not autoimmunity. Cancer Research, 67: 5929-5939
Wang, H-J., Leege, T., Shayakhmetov, D., Li, Q., Papayannopoulou, T., Stamatoyannopolous, G., Lieber, A. (2005) A capsid-modified helper-dependent adenovirus vector containing the beta-globin locus control region displays a non-random integration pattern and allows for stable, erythroid-specific gene expression. Journal of Virology, 79: 10999-1013
Sova, P. Ren, X-W., Ni, S. Bernt, K., Mi, J., Kiviat, N., Lieber, A. (2004) A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. Molecular Therapy, 9: 496-509
Gaggar, A., Shayakhmetov, D.M., Lieber, A. (2003) CD46 is a cellular receptor for group B adenovirus. Nature Medicine, 9: 1408-12
Steinwaerder, D.S., Carlson, C.A., Otto, D.L., Li, Z-Y., Ni, S., Lieber, A. (2001) Tumor specific gene expression in hepatic metastases by a replication-activated adenovirus vector. Nature Medicine, 7: 2140-243
©2003 Division
of Medical Genetics, University of Washington.
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Design by Jessie Good
Last updated: April 28, 2003
