Qiliang Li, Ph.D.
Research Professor of Medicine
I-164F Health Sciences Building
Medical Genetics, Box 357720
Phone: 206-616-4526
FAX: 206-616-4527
E-mail: li111640@u.washington.edu
Dr. Li’s general research interests focus on the field of expression
regulation of eukaryotic genes, in particular, the mechanism of long-range
interaction between the locus control region (LCR)/enhancer and promoters
using the globin locus as the model. High-level expression of ß-like globin gene is dependent on the presence of
the LCR, which is located several kb away from the genes. The LCR is able
to activate the genes in a gene- and developmental stage-specific manner.
The activation may be exerted by a chromatin looping mechanism, which
bring the LCR and genes to a proximal distance. Past studies include
identification of ß-globin LCR in goat and definition of insulating
activity of DNase I hypersensitive site 5’ of the human LCR. Current
studies focus on the investigation of relative parameters involved in
looping formation, including identification of cis elements participating
in interaction of the LCR and promoters, identification and
characterization of trans factors that regulate the interaction, and
analysis of chromatin structure.
Investigator: Dr. Li is a Research Professor in the Department of Medicine (Medical Genetics).
©2003 Division
of Medical Genetics, University of Washington.
All rights reserved.
Design by Jessie Good
Last updated: March 30, 2004
