Dec. 3, 1999
A "ribbon diagram" of the of the structure of the hemophilia domain of human factor VIII
In this figure, the positions in the protein fold that are found to be
mutated in patients with hemophilia A are shown by spheres. Dark
spheres are sites that display severe defects in clotting when mutated;
light spheres are sites that display milder defects. The atoms at the
bottom of the protein are amino acids thought to embed themselves into
exposed membranes at sites of blood-vessel damage.
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