Past Events

Tuesday, February 19, 2019 at 5 pm in CHB 102.
(Hopefully not) Too Hot to Handle: the Internal Energies of Ions During IM
Matt Bush will present a brief overview of the contemporary understanding of heating during ion mobility experiments.
Discussion: Multiplexing of Time-Dispersive  IM Measurements
We will discuss efforts by the IM community to improve the duty cycle of IM measurements. Before the meeting, participants should read “Pseudorandom Sequence Modifications for Ion Mobility Orthogonal Time-of-Flight Mass Spectrometry” by Clowers et al. LINK

December 12, 2018 | Dr. John C. Fjeldsted (Agilent Technologies)

    • John C. Fjeldsted is Agilent’s senior director of LC/MS Research and Development. He presented on the Agilent IM-MS platform and recent developments in IM-MS.

September 21, 2018 | Prof. Chris Hogan (University of Minnesota)

    • We were delighted to host Prof. Hogan, who presented a seminar titled “Ion Mobility Spectrometry: Beyond Separation and Structural Characterization”.

July 10, 2018 | Targeted Analysis of Ion Mobility Data

    • We were pleased to hear from Brian Pratt and Brendan MacLean about recent progress on the use of Skyline for the analysis ion mobility mass spectrometry data.
    • Skyline is a freely-available, open-source Windows client application for building Selected Reaction Monitoring (SRM) / Multiple Reaction Monitoring (MRM), Parallel Reaction Monitoring (PRM), DIA/SWATH and targeted DDA quantitative methods and analyzing the resulting mass spectrometer data. Its flexible configuration supports All Molecules. It aims to employ cutting-edge technologies for creating and iteratively refining targeted methods for large-scale quantitative mass spectrometry studies in life sciences.
    • Originally developed for proteomics, Skyline has been extended by popular demand to work with generalized molecules. An important aspect of this work has been to enable the use of ion mobility separation equipment offered by the major mass spec vendors in support of experimental regimes where chromatography alone is often insufficient to distinguish molecules of nearly identical mass.
    • Additional background on Skyline is available from

May 29, 2018

    • Lightning Talks
        • Ion Mobility of Proteins in Nitrogen Gas: Effects of Charge State, Charge Distribution, and Structure Characterized using Trajectory Method Calculations. (Daniele Canzani, Bush Lab)
        • Internal Exchange Standards Enable Cross-Platform Reproducibility in Measuring Gas-Phase Hydrogen/Deuterium Exchange Kinetics by Mass Spectrometry. (Sanjit S. Uppal (Sunny), Guttman Lab)
        • Collision-Induced Unfolding and Dissociation Reveal the Location of Ni(II) Binding in the Dimer of the Alpha-Crystallin Domain of HSPB5. (Cece Hong, Bush Lab)
        • Site-specific differentiation of sialic acid linkage isomers by ion mobility and gas-phase H/D exchange. (Mike Guttman)
    • Memory of the Condensed-Phase in the Gas-Phase: Effects of Solution, Charge, and Energy on Structures of Serum Albumin Ions. (Meagan Gadzuk-Shea, Bush Lab)

April 11, 2018

    • Lipidomics by HILIC-ion mobility-mass spectrometry. (Dr. Kelly Hines, Xu Lab)
    • Discussion: Prediction of Collision Cross-Section Values with Machine Learning

January 17, 2018

    • Using Ion Mobility Mass Spectrometry for Structural Elucidation of Glycans (Dr. Abhigya Mookherjee, Guttman Lab)
    • Determining Absolute Collision Cross Sections of Glycans (Daniele Canzani, Bush Lab)