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Han Photo 1[1]

Chang Yeop Han, Ph.D.

Metabolism, Endocrinology and Nutrition

Research Assistant Professor of Medicine


Focus

Dr. Han's research focuses on the adipose tissue inflammation in obesity. Obesity is characterized by adipocyte hypertrophy and accumulation of macrophages in adipose tissue. Both adipocytes and macrophages secrete a number of pro-inflammatory molecules, which may lead to insulin resistance, systemic inflammation and cardiovascular disease. He is especially interested in how adipocytes produce chemotactic factors to recruit monocytes and extracellular matrix molecules to increase the adhesion of macrophages by nutrient excess such as excess glucose and various free fatty acids. He is studying potential mechanisms involved in reactive oxygen species, interaction between NFKB and PPAR, Toll-like receptor and NADPH oxidase at hypertrophic adipocyte. He is also studying how adipocytes cross-talk with macrophage to determine the phenotype of macrophage in obesity.



Publications


Han CY and Lee S. H. Yi : Identification of proacrosin binding protein precursor in the In vitro translation of boar testicular poly(A)+-mRNA. Mol Cells 6: 341-345, 1996

Han CY and Pak YK:  Oxidation dependent effects of oxidized LDL: proliferation or cell death.  Exp Mol Med 31:165-173, 1999.

Han CY, Park SY and Pak YK:  Role of endocytosis in the transactivation of nuclear factor- oxidized low density lipoprotein.  Biochem J 350:829-837, 2000.

Kim YS, Han CY, Kim SW, Kim JH, Lee SK, Jung DJ, Park SY, Kang H, Choi HS, Lee JW and Pak YK:  The orphan nuclear receptor small heterodimer B in oxidized low density kB partner as a novel coregulator of nuclear factor- lipoprotein-treated macrophage cell line RAW264.7. J Biol Chem 276:33736-33740, 2001.

Park KS, Nam KJ, Kim JW, Lee YB, Han CY, Jeong JK, Lee HK and Pak YK:  Depeletion of mitochondria DNA alters glucose metabolism in SK-Hep1 cells.  Am J Physiol Endocrinol Metab 280:E1007-E1014, 2001.

Kim I, Moon SO, Han CY, Pak YK, Moon SK, Kim JJ and Koh GY:  The angiopoietin-tie2 system in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis.  Cardiovascular Research 49:872-881, 2001.

Chait A, Han CY, Oram JF and Heinecke JW:  Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins:  markers or mediators of cardiovascular disease?  J Lipid Res 46:389-403, 2005.

Chang MY, Han CY, Wight TN and Chait A:  Antioxidants inhibit the ability of lysophosphatidylcholine to regulate proteoglycan synthesis.  Arterioscler Thromb Vasc Biol 26:494-500, 2006.

Han CY, Campbell JS, Fausto N, Chaisson M, Orasanu G, Plutzky J and Chait A:  Reciprocal regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocyte.  Arterioscler Thromb Vasc Biol 26:1806-1813, 2006.

Han CY, Subramanian S, Chan CK, Omer M, Chiba T, Wight TN and Chait A: Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 56:2260-2273, 2007.

Subramanian S, Han CY, Chiba T, McMillen T, Wang SA, Kirk  EA, O’Brien KD, and Chait A: Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese, insulin resistant LDL receptor-deficient mice.  Arterioscler Thromb Vasc Biol 28:685-691, 2008.

Chiba T, Han CY, Shimokado K, Chen M, Wang S, Vaisar T, Heinecke JW, and Chait A: Serum amyloid A3 (SAA3), an adipocyte-derived inflammatory protein, does not contribute directly to the increased circulating SAA levels seen in obese mice. J Lipid Res 50:1353-1362, 2009.

Han CY, Kargi AY, Omer M, Chan CK, O’Brien KO, Wight TN and Chait A:  Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. Diabetes  59:386-396, 2010

Handa P, Tateya S, Rizzo NO, Cheng AM, Morgan-Stevenson V, Han CY, Clowes AW, Daum G, O’Brien K, Schwartz MW, Chait A, and Kim F. Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding. Arterioscler Thromb Vasc Biol 31:2827-283, 2011

Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller C, Sweet IR, Pennathur S, Abel ED and Chait A. NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. J Biol Chem 287:10379-93, 2012