Skip to Content

taborsky

Gerald J. Taborsky, Jr., Ph.D.

Metabolism, Endocrinology and Nutrition

Research Professor of Medicine


Focus

Role of the autonomic nervous system in mediating the glucagon response to hypoglycemia. Impairments in sympathetic neural pathways in autoimmune diabetes. Contribution of the parasympathetic nervous system to the insulin response to oral glucose.



Publications

Dunning, B.E., Ahren, B., Veith, R.C., Bottcher, G., Sundler, F., and Taborsky, G.J., Jr.:  Galanin:  A novel pancreatic neuropeptide.  Am. J. Physiol. 251:E127-E133, 1986.

Ahren, B., Veith, R.C., Taborsky, G.J., Jr.:  Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog:  1) Effects on basal release of insulin and glucagon.  Endocrinology 121:323-331, 1987.

Ahren, B., Dunning, B.E., Havel, P.J., Veith, R.C., Taborsky, G.J.,Jr.:  Extraction of epinephrine and norepinephrine by the dog pancreas in vivo.  Metabolism 37:68-73, 1988.

Havel, P.J., Veith, R.C., Dunning, B.E., Taborsky, G.J., Jr.:  Pancreatic noradrenergic nerves are activated by neuroglucopenia but not hypotension or hypoxia in the dog:  Evidence for stress-specific and regionally-selective activation of the sympathetic nervous system.  J. Clin. Invest. 82:1538-1545, 1988.

Dunning, B.E., Taborsky, G.J.,Jr.:  Galanin release during pancreatic nerve stimulation is sufficient to influence islet function.  Am. J. Physiol. 256:E191-198, 1989.

Dunning, B.E., Havel, P.J., Veith, R.C., Taborsky, G.J.,Jr.:  Pancreatic and extrapancreatic galanin release during sympathetic neural activation.  Am. J. Physiol. 258:E436-E444, 1990.

Havel, P.J., Veith, R.C., Dunning, B.E., Taborsky, G.J. Jr.: Role for the autonomic nervous system to increase pancreatic glucagon secretion during marked insulin-induced hypoglycemia in dogs. Diabetes 40:1107-1114, 1991.

Greenbaum, C.J., Havel, P.J., Taborsky, G.J., Jr., Klaff, L.J.:  Intraislet insulin permits glucose to directly suppress pancreatic A cell function.  J. Clin. Invest. 88:767-773, 1991.

McKnight, G.L., Karlsen, A.E., Kowalyk, S., Mathews, S.L., Sheppard, P.O., O’Hara, P.J., Taborsky, G.J.,Jr.:  Sequence of human galanin and its inhibition of glucose-stimulated insulin secretion from RIN cells.  Diabetes 41:82-87, 1992.

Scheurink, A.J.W., Mundinger, T.O., Dunning, B.E., Veith, R.C., Taborsky, G.J,Jr.:  a2-Adrenergic regulation of galanin and norepinephrine release from canine pancreas.  Am. J. Physiol. 262:R819-R825, 1992.

Havel, P.J., Mundinger, T.O., Veith, R.C., Dunning, B.E., Taborsky, G.J.,Jr.:  Co-release of galanin and norepinephrine from pancreatic sympathetic nerves during severe hypoglycemia in dogs.  Am. J. Physiol. 263:E8-E16, 1992.

Boyle, M.R., Verchere, C.B., McKnight, G., Mathews, S., Walker, K., Taborsky, G.J. Jr.: Canine galanin: sequence, expression, and pancreatic effects. Reg. Peptides 50:1-11, 1994.

Taborsky, G.J., Jr., Beltramini, L., Brown, M., Veith, R., Kowalyk, S.:  The canine liver releases Neuropeptide Y during sympathetic nerve stimulation.  Am. J. Physiol. 266:E804-E812, 1994.

Verchere, C.B., Kowalyk, S., Shen, G.H., Brown, M.R., Schwartz, M.W., Baskin, D.G., Taborsky, G.J. Jr.: Major species variation in the expression of galanin mRNA in mammalian celiac ganglia. Endocrinology 135:1052-1059, 1994.

Havel, P.J., Parry, S.J., Stern, J.S., Akpan, J.O., Gingerich, R.L., Taborsky, G.J. Jr., Curry, D.L. Redundant parasympathetic and sympathoadrenal mediation of increased glucagon secretion during insulin-induced hypoglycemia in conscious rats. Metabolism 43:860-866, 1994.

Havel, P.J., Mundinger, T.O., Taborsky, G.J.,Jr.:  Pancreatic sympathetic nerves contribute to increased glucagon secretion during severe hypoglycemia in dogs.  Am. J. Physiol. 270: E20-E26, 1996.

Verchere, C.B.,  Kowalyk, S., Koerker, D.J., Baskin, D.G., Taborsky, G.J., Jr.:  Evidence that galanin is a parasympathetic, rather than sympathetic, neuropeptide in baboon pancreas. Reg. Peptides 67:93-101, 1996.

Mundinger, T.O., Boyle, M.R., Taborsky, G.J., Jr.:  Activation of hepatic sympathetic nerves during hypoxic, hypotensive and glucopenic stress.  J. Auton. Nerv. Syst.  63:153-160, 1997.

Havel, P.J., Dunning, B.E., Verchere, C.B., Baskin, D.G., O’Dorisio, T.M., Taborsky, G.J.,Jr.: Evidence that vasoactive intestinal polypeptide is a parasympathetic neurotransmitter in the endocrine pancreas in dogs. Reg. Peptides 71:163-170, 1997.

Mundinger, T.O., Verchere, C.B., Baskin, D.G., Boyle, M.R., Kowalyk, S., Taborsky, G.J., Jr.:  Galanin is localized in sympathetic neurons of the dog liver.  Am. J. Physiol. 273:E1194-E1202, 1997.

Benthem, L., Taborsky, G.J., Jr.:  Hyperglycemia suppresses the sympatho-adrenal response to hypoxia, but not to handling stress.  J. Auton. Nerv. Syst. 73:149-155, 1998.

Mundinger, T.O., Taborsky, G.J., Jr.:  Differential action of hepatic sympathetic neuropeptides: metabolic action of galanin, vascular action of NPY.   Am J Physiol. 41:E390-97, 2000.

Benthem, L., Mundinger, T.O., Taborsky, G.J., Jr.:  Meal-induced insulin secretion in dogs is mediated by both branches of the autonomic nervous system. Am J Physiol 278:E603-610, 2000.

D’Alessio, D., Kieffer, T. J., Taborsky, G. J., Jr., Havel P. J.:  Activation of the parasympathetic nervous system contributes to meal-induced insulin secretion in rhesus macaques.  J. Clin. Endo Metab. 86:1253-1259, 2001.

Benthem, L., Mundinger, T.O., Taborsky, G.J., Jr.: Parasympathetic inhibition of sympathetic neural activity to the pancreas. Am J Physiol 280:E378-E381, 2001.

Mei, Q., Mundinger, T. O., Kung, D., Baskin, D. G., Taborsky, G. J., Jr.:  Fos expression in rat celiac ganglion: an index of the activation of post-ganglionic sympathetic nerves.  Am J Physiol 281:E655-E664, 2001.

Ahren B, Taborsky GJ, Jr., Havel PJ: Differential impairment of glucagon responses to hypoglycemia, neuroglycopenia, arginine, and carbachol in alloxan-diabetic mice. Metabolism 51:12-19, 2002.

Mei, Q., Mundinger, T. O., Lernmark, A., Taborsky, G. J., Jr.  Early, selective and marked loss of sympathetic nerves from the islets of BB diabetic rats. Diabetes 51:2997-3002, 2002.

Yang, L., Mei, Q., Zielinska-Kwiatkowska, A., Matsui, Y., Matsui, Y., Taborsky, G. J., Jr., Chansky, H. A.: An ERG-associated histone methyltransferase interacts with histone deacetylases and mSin3 transcription corepressorsESET histone methyltransferase associates with histone deacetylases and mSin#3 transcription corepressors. Biochem J 369:651-657, 2003.

Evans S.B., Wilkinson, C.W., Gronbeck,  P, Bennett, J.L., Taborsky,  G.J. Jr., Figlewicz DP: Inactivation of the paraventricular nucleus of the hypothalamus during hypoglycemia partially simulates hypoglycemia associated autonomic failure. Am  J. Physiol 284:R57-R65, 2003.

Mundinger, T.O., Mei, Q., Figlewicz, D. P., Lernmark, A., Taborsky, G. J., Jr.: Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: an effect of early sympathetic islet neuropathy (eSIN). Am J. Physiol 285: E1047-1054, 2003.

Evans, S.B., Wilkinson, C.W., Gronbeck, P., Bennett, J.L., Zavosh, A., Taborsky,  G.J., Jr., Figlewicz D.P.: Inactivation of the dorsomedial nucleus of the hypothalamus selectively inhibits the ACTH and corticosterone responses to hypoglycemia. Am J Physiol 286:R 123-128, 2004.

Mei, Q., Mundinger, T.O., Lernmark, A., Taborsky, Jr., G.J.: Increased Galanin Expression in the Celiac Ganglion of BB Diabetic Rats. Neuropeptides 40:1-10, 2006.

Sanders, N.M., Figlewicz, D.P., Taborsky, G.J., Jr., Wilkinson, C.W., Daumen, W., Levin, B.E.: Feeding and neuroendocrine response after recurrent insulin-induced hypoglycemia. Physiol Behav 87:700-706, 2006.

Mundinger, T.O., Cummings, D.E., Taborsky, G.J., Jr.:  Direct Stimulation of Ghrelin Secretion by Sympathetic Nerves.  Endocrinology 147:2893-2901, 2006.

Sanders, N.M., Taborsky, G.J., Jr., Wilkinson, C.W., Daumen, W., Figlewicz, D.P.:  Antecedent hindbrain glucoprivation does not impair the counterregulatory response to hypoglycemia.  Diabetes 56:217-223, 2007.

Gilliam, L.K., Palmer, J.P., Taborsky, G.J.Jr.: Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humans. J Clin Endocrinol Metab 92:4035-8, 2007.

Al-Noori, S., Sanders, N.M., Taborsky, G.J., Jr., Wilkinson, C.W., Figlewicz, D.P.: Acute THPVP inactivation decreases the glucagon and sympathoadrenal response to recurrent hypoglycemia. Brain Res. 1194:65-72, 2007.

Sanders, N.M., Wilkinson, C.W,. Taborsky, G.J.,Jr., Al-Noori, S., Daumen, W., Zavosh, A., Figlewixz, D.P. The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia. Am J Physiol Endocrinol Metab. 294:E853-60, 2008.

Mundinger,T.O., Mei, Q., Taborsky, G.J., Jr. Impaired activation of celiac ganglion neurons in vivo after damage to their sympathetic nerve terminals. J Neurosci Res. 86:1981-93, 2008.

Al-Noori, S., Sanders, N.M., Taborsky, G.J. Jr., Wilkinson, C.W., Zavosh, A., West, C., Sanders, C.M., Figlewicz, D.P.: Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin. Amer. J. Physiol. Regul Integr Comp Physiol 295: R1446-R1454, 2008.

Taborsky, G.J. Jr., Mei, Q., Hackney, D.J., Figlewicz, D.P., LeBoeuf, R., Mundinger, T.O.: Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitis. Diabetologia, 52:2602-11, 2009.

German, J.P., Wisse, B.E., Thaler, J.P., Oh-I, S., Sarruf, D.A., Ogimoto, K., Fischer, J. D., Matsen, M.E., Taborsky, G.J.,Jr., Schwartz, M.W., Morton, G.J.: Leptin deficiency and insulin resistance. Diabetes. 59:1626-34, 2010.

German, J.P., Thaler, J.P., Wisse, B.E., Oh-I, S., Sarruf, D.A., Matsen, M.E., Fischer, J.D., Taborsky, G.J., Schwartz, M.W., Morton, G.J. Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia. Endocrinology. 152:394-404, 2011.