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Irl B. Hirsch, M.D.

Metabolism, Endocrinology and Nutrition

Professor of Medicine


Using new technologies to improve diabetes therapy, particularly with the use of real-time continuous glucose sensors. I am also interested in the use of insulin for in-patient diabetes, and the non-glycemic effects of insulin, particularly its anti-inflammatory actions. I have recently focused on the role of glycemic variability in the pathogenesis of diabetes-related complications.


Hirsch IB, Tsai E, Atchley D, Labbe R, Chait A: Ascorbic acid clearance in diabetic nephropathy. J Diabetes Complications, 12:259-263, 1998.

Hirsch IB, Goldberg HI, Ellsworth A, Evans TC, Herter CD, Ramsey SD, Mullen M, Neighbor WE, Cheadle AD: A multifaceted intervention in support of diabetes treatment guidelines: a controlled trial. Diabetes Res Clin Pract 58:27-36, 2002.

Clement S, Braithwait S, Magee M, Ahmann A, Smith, EP, Schafer RP,  Hirsch IB: Technical Review: Management of diabetes and hyperglycemia in hospitals. Diabetes Care 27:553-97, 2004.

Hirsch IB: Insulin analogues. N Engl J Med, 352:174-83, 2005.

Hirsch IB, Abelseth J, Bode BW, Fischer JS, Kaufman FR, Mastrototaro J, Wolpert H, Buckingham BA: Sensor-augmented pump therapy: results of the first randomized treat-to-target study. Diabetes Technol Ther 10:377-83, 2008

The Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group: Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med 359:1464-78, 2008.

Hammer MJ, Casper C, Gooley TA, O’Donnell PV, Boeckh M, Hirsch IB: The contribution of malglycemia to mortality in among allogenic hematopoietic cell transplant recipients. Biol Blood Marrow Transplant 15:344-51, 2009

Hirsch, IB: Sliding Scale Insulin: Time to Stop Sliding. JAMA 14:213-14, 2009.

Brownlee M, Hirsch IB: Glycemic variability: a HbA1c-independent risk factor for diabetic complications. JAMA 295:1707-8, 2006

Hirsch IB: Home blood glucose monitoring in type 2 diabetes: broken health care system undermines study’s impact. Diabetes Care 34:527-528, 2011