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J. Ernie Blevins, Ph.D.

Metabolism, Endocrinology and Nutrition

Research Associate Professor of Medicine


Focus

Brain pathways regulating leptin signaling from the hypothalamus to the brainstem linked to the control of food intake, neuroanatomical techniques-for mapping neural circuits (oxytocin, corticotropin releasing hormone) involved with mediating the effects of leptin on food intake and energy expenditure, and histochemical methods (immunocytochemistry and in situ hybridization) for detecting the expression of neural genes involved in the regulation of energy homeostasis.


Publications

Blevins, J.E., Eakin, T.J., Murphy, J.A., Schwartz, M.W., and D.G. Baskin.  Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin.  Brain Res. 993:  30-41, 2003.

Blevins, J.E., Schwartz, M.W., and D.G. Baskin.  Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brainstem nuclei controlling meal size.  Am. J. Physiol. 287:  R87-96, 2004.

Blevins, J.E., Truong, B.G., and D.W. Gietzen.  NMDA receptor function within the anterior piriform cortex and lateral hypothalamus in rats on the control of intake of amino acid-deficient diets.  Brain Res. 1019:  124-133, 2004.

Morton, G.J, Blevins, J.E., Niswender, K.D., Gelling, R.W., Rhodes, C.J., Baskin, D.G. and M.W. Schwartz.  Leptin action in the forebrain regulates the hindbrain response to satiety signals:  A mechanism linking body fat mass to the control of meal size.  J. Clin. Invest. 115:  703-710, 2005.

Coppola, J.D., Horwitz, B.A., Hamilton, J., Blevins, J.E., and R.B. McDonald.  Reduced feeding response to muscimol and neuropeptide Y in senescent F344 rats.  Am. J. Physiol. 288:  R1492-1498, 2005.

Williams, D.L., Schwartz, M.W., Bastian, L.S., Blevins, J.E., and D.G. Baskin.  Immunocytochemistry and laser capture microdissection for real-time quantitative PCR identify hindbrain neurons activated by interaction between leptin and cholecystokinin.  J. Histochem. Cytochem. 56:  285-293, 2008.

Blevins, J.E., Chelikani, P.K., Haver, A.C., and R.D. Reidelberger.  PYY(3-36) Induces Fos in the Arcuate Nucleus and in both Catecholaminergic and Non-catecholaminergic Neurons in the Nucleus Tractus Solitarius of Rats.  Peptides.  29:112-119, 2008.

Blevins, J.E., Morton, G.J., Williams, D.L., Caldwell, D.W., Bastian, L.S., Wisse, B.E., Schwartz, M.W., and D.G. Baskin.  Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8.  Am. J. Physiol. 296:  R476-R484, 2009.

Blevins, J.E., Overduin, J., Fuller, J.M., Cummings, D.E., Matsumoto, K., and D.H. Moralejo.  Normal feeding and body weight in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.  Brain Res. 1255:98-112, 2009.

Morton, G.J., Blevins, J.E., Kim, F., Matsen, M., and D.P. Figlewicz.  The action of leptin in the ventral tegmental area to decrease food-intake is dependent on Jak-2 signaling. Am. J. Physiol. 297:  E202-E210, 2009.

Baskin, D.G., Kim, F., Gelling, R.W., Russell, B.J., Schwartz, M.W., Morton, G.J., Simhan, H.N., Moralejo, D.H., and J.E. Blevins.  A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain.  Endocrinology 151:  4207-4213, 2010.

Blevins, J.E. and D.G. Baskin.  Hypothalamic-brainstem Circuits Controlling Food Intake.  In:  Frontiers in Eating and Weight Regulation.  W. Langhans and N. Geary, eds. S Karger AG, Basel, 2010:  pp. 133-140.

Roth, C.L., Blevins, J.E., Ralston, M., Elfers, C., Ogimoto, K., Kaiyala, K.J., and G.J. Morton.  A novel rodent model that mimics the metabolic sequelae of obese craniopharyngioma patients.  Pediatric Research 69:  230-236, 2011.

Morton, G.J., Thatcher, B.S., Reidelberger, R.D., Ogimoto, K., Wolden-Hanson, T.H., Baskin, D.G., Schwartz, M.W., and J.E. Blevins.  Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats.  Am. J. Physiol. 302:  E1334-44, 2012.

Reidelberger, R.D, Haver, A.C., Chelikani, P.K., Apenteng, B., Perriotte-Olson, C., Anders, K., Steenson, S., and J.E. Blevins.  Effects of leptin replacement alone and with exendin-4 on food intake and weight regain in weight-reduced diet-induced obese rats.  Am. J. Physiol. 302:  E1576-1585, 2012.

Blevins, J.E., Moralejo, D.H., Wolden-Hanson, T.H., Thatcher, B.S., Ho, J.M., Kaiyala, K.J., and K. Matsumoto.  Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.  Am. J. Physiol., 303:  1231-1240, 2012.

Ho, J.M. and J.E. Blevins.  Coming full circle: contributions of central and peripheral oxytocin actions to energy balance. Endocrinology 154:  589-596, 2013.

Blevins, J.E., and J.M. Ho.  Role of oxytocin signaling in the regulation of body weight.  Rev Endocr. Metab.Disord. 14 :311-29, 2013.