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J. Ernie Blevins, Ph.D.

Metabolism, Endocrinology and Nutrition

Research Associate Professor of Medicine


Focus

Brain pathways regulating leptin signaling from the hypothalamus to the brainstem linked to the control of food intake, neuroanatomical techniques-for mapping neural circuits (oxytocin, corticotropin releasing hormone) involved with mediating the effects of leptin on food intake and energy expenditure, and histochemical methods (immunocytochemistry and in situ hybridization) for detecting the expression of neural genes involved in the regulation of energy homeostasis.


Publications

Arnelo U, Blevins JE, Larrson J, Permert J, Westermark P, Reidelberger RD, and Adrian TE:  Effects of acute and chronic infusion of islet amyloid polypeptide on food intake in rats.  Scand J Gastroenterol 31:83-89, 1996.

Blevins JE, Havel PJ, and Gietzen, DW:  Injections of leptin into the anterior piriform cortex inhibit food intake in rats.  Nut. Neurosci 2/5:357-367, 1999.

Blevins JE, Stanley BG, and Reidelberger RD:  Brain sites where CCK suppresses feeding in rats. Brain Res 860:1-10, 2000.

Blevins JE, Hamel FG, Stanley BG, and Reidelberger RD:  Effects of paraventricular nucleus injection of CCK-8 on plasma CCK-8 levels in rats.  Brain Res 860:11-20, 2000.

Blevins JE, Dixon KD, Hernandez EJ, Barrett JA, and Gietzen DW: Effects of threonine injections in the lateral hypothalamus on intake of amino acid imbalanced diets in rats.  Brain Res 879:65-72, 2000.

Blanton CA, Horwitz BA, Blevins JE, Hamilton J, Hernandez E J, and McDonald RB:  Reduced feeding response to neuropeptide Y in senescent Fischer 344 rats.  Am J Physiol 280:R1052-R1060, 2001.

Saleh J, Blevins JE, Havel PJ, Barrett JA, Gietzen DW, Sniderman AD, and Cianflone K:  Acylation stimulating protein (ASP) effect on postprandial lipemia and food intake in rodent models.  Int J Obes25:705-713, 2001.

Blevins JE, Stanley BG, and Reidelberger RD:  DMSO as a vehicle for central injections:  tests with feeding elicited by norepinephrine injected into the paraventricular nucleus.  Pharmacol Biochem Behav71:277-282, 2002.

Niswender KD, Gallis B, Blevins JE, Corson MA, Schwartz MW, and Baskin DG:  Immunocytochemical detection of phosphastidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem 51:275-83, 2003.

Morton G J, Niswender KD, Rhodes CJ, Meyers Jr MG, Blevins JE, Baskin DG, and Schwartz MW:  Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of koletsky(fak/fak) rats.  Endocrinol 144:2016-24, 2003.

Russel MC, Koehnle TJ, Barrett JA, Blevins JE, and Gietzen DW: The rapid anorectic response to a threonine imbalanced diet is decreased by injection of threonine into the anterior piriform cortex of rats.  Nutr Neurosci 6:247-51, 2003.

Blevins JE, Teh PS, Wang CX, and Gietzen DW:  Effects of amino acid deficiency on monoamines in the lateral hypothalamus (LH) in rats.  Nutr Neurosci 6:291-99, 2003.

Blevins JE, Eakin TJ, Murphy JA, Schwartz MW, and Baskin DG:  Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin.  Brain Res 993:30-41, 2003.

Blevins JE, Truong BG, and Gietzen DW:  NMDA receptor function within the anterior piriform cortex and lateral hypothalamus in rats on the control of intake of amino acid-deficient diets.  Brain Res 1019:124-133, 2004.

Blevins JE, Schwartz MW, and Baskin DG:  Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brainstem nuclei controlling meal size.  Am J Physiol 287:R87-R96, 2004.

Morton GJ, Blevins JE, Niswender KD, Gelling RW, Rhodes CJ, Baskin DG, Schwartz MW:  Leptin action in the forebrain regulates the hindbrain response to satiety signals:  A mechanism linking body fat mass to the control of meal size.  J Clin Invest 115:703-710, 2005.

Coppola JD, Horwitz BA, Hamilton J, Blevins JE, McDonald RB:  Reduced feeding response to muscimol and neuropeptide Y in senescent F344 rats.  Am J Physiol 288:R1492-R1498, 2005.