Karen E. Foster-Schubert, M.D.
Metabolism, Endocrinology and Nutrition
Associate Professor of Medicine
Dr. Foster-Schubert’s research focus is on human obesity and body weight regulation. She has investigated the role of exercise-induced weight loss and macronutrient effects on the orexigenic hormone ghrelin, as well as ghrelin’s effects on islet insulin release. Current research projects are aimed at the following: 1) hormonal and physiologic predictors (including alterations in adipose gene expression) of successful weight loss maintenance following diet and exercise interventions; 2) the effect of varying dietary energy density on body weight regulatory hormones and appetite; 3) development of a novel imaging method to measure parameters of hypothalamic regulation of body weight in humans, using a multi-disciplinary approach.
Cummings DE, Overduin J, Foster-Schubert KE: Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 89:2608-2615, 2004.
Cummings DE, Overduin J, Shannon MH, Foster-Schubert KE; 2004 ABS Consensus Conference: Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgery. Surg Obes Relat Dis 1:358-68, 2005.
Cummings DE, Foster-Schubert KE, Overduin J: Ghrelin and energy balance: focus on current controversies. Curr Drug Targets 6:153-69, 2005.
Foster-Schubert KE, McTiernan A, Frayo RS, Schwartz RS, Rajan KB, Yasui Y, Tworoger SS, Cummings DE: Human plasma ghrelin levels increase during a one-year exercise program. J Clin Endocrinol Metab 90:820-825, 2005.
Foster-Schubert KE, Cummings DE: Emerging therapeutic strategies for obesity. Endocr Rev 27:779-93, 2006.
Cummings DE, Overduin J, Foster-Schubert KE, Carlson MJ: Role of the bypassed proximal intestine in the anti-diabetic effects of bariatric surgery. Surg Obes Relat Dis 3:109-15, 2007.
Littman AJ, Vitiello MV, Foster-Schubert K, Ulrich CM, Tworoger SS, Potter JD, Weigle DS, McTiernan A: Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention. Int J Obes (Lond). 31:466-75, 2007.