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Karen E. Foster-Schubert, M.D.

Metabolism, Endocrinology and Nutrition

Associate Professor of Medicine


Dr. Foster-Schubert’s research focus is on human obesity and body weight regulation. She has investigated the role of exercise-induced weight loss and macronutrient effects on the orexigenic hormone ghrelin, as well as ghrelin’s effects on islet insulin release. Current research projects are aimed at the following: 1) hormonal and physiologic predictors (including alterations in adipose gene expression) of successful weight loss maintenance following diet and exercise interventions; 2) the effect of varying dietary energy density on body weight regulatory hormones and appetite; 3) development of a novel imaging method to measure parameters of hypothalamic regulation of body weight in humans, using a multi-disciplinary approach.


Cummings DE, Overduin J, Foster-Schubert KE:  Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution.  J Clin Endocrinol Metab 89:2608-2615, 2004.

Cummings DE, Overduin J, Shannon MH, Foster-Schubert KE; 2004 ABS Consensus Conference:  Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgery.  Surg Obes Relat Dis 1:358-68, 2005.

Cummings DE, Foster-Schubert KE, Overduin J:  Ghrelin and energy balance: focus on current controversies.  Curr Drug Targets 6:153-69, 2005.

Foster-Schubert KE, McTiernan A, Frayo RS, Schwartz RS, Rajan KB, Yasui Y, Tworoger SS, Cummings DE:  Human plasma ghrelin levels increase during a one-year exercise program.  J Clin Endocrinol Metab 90:820-825, 2005.

Foster-Schubert KE, Cummings DE:  Emerging therapeutic strategies for obesity.  Endocr Rev 27:779-93, 2006.

Cummings DE, Overduin J, Foster-Schubert KE, Carlson MJ:  Role of the bypassed proximal intestine in the anti-diabetic effects of bariatric surgery.  Surg Obes Relat Dis 3:109-15, 2007.

Littman AJ, Vitiello MV, Foster-Schubert K, Ulrich CM, Tworoger SS, Potter JD, Weigle DS, McTiernan A:  Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention.  Int J Obes (Lond). 31:466-75, 2007.