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kristina

Kristina Utzschneider, M.D.

Metabolism, Endocrinology and Nutrition

Associate Professor of Medicine


Focus

Dr. Utzschneider's research focuses on the interaction between liver disease and glucose metabolism. One study investigates the effect of iron overload due to hereditary hemochromatosis on insulin sensitivity and beta-cell function. A second study attempts to better understand the mechanisms linking non-alcoholic fatty liver disease and insulin resistance. In addition, she continues to study the relationship between measures of insulin response and insulin sensitivity using measures derived from an oral glucose tolerance test.


Publications

Utzschneider KM, Carr DB, Barsness SM, Kahn SE and Schwartz RS:  Diet-induced weight loss is associated with an improvement in ß-cell function in older men.  J Clin Endocrinol Metab 89:2704-2710, 2004.

Utzschneider KM, Carr DB, Hull RL, Kodama K, Shofer JB, Retzlaff BM, Knopp RH and Kahn SE:  Impact of intra-abdominal fat and age on insulin sensitivity and ß-cell function.  Diabetes 53:2867-2872, 2004.

Utzschneider KM, Carr DB, Tong J, Wallace TM, Hull RL, Zraika S, Xiao Q, Mistry JS, Retzlaff BM, Knopp RH and Kahn SE:  Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans.  Diabetologica, accepted for publication 2005.

Utzschneider KM, Carr DB, Hull RL, Tong J, ShoferJB,  PrigeonRL, Retzlaff BM, Knopp RH and Kahn SE: Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses. Diabetes Care 29:356-62, 2006.

Utzschneider KM and Kahn SE: The role of insulin resistance in non-alcoholic steatohepatits. Journal of Clinical Endocrinology and Metabolism 91:4753-61, 2006.

Utzschneider KM, Prigeon RL, Carr DB, Hull RL, Tong J, Shofer JB, Retzlaff BM, Knopp RH, Kahn SE:  Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses. Diabetes Care 29:356-62, 2006

Utzschneider KM, Prigeon RL, Tong J, Gerchman F, Carr DB, Zraika S, Udayasankar J, Montgomery B, Mari A, Kahn SE: Within subject variability of measures of β-cell function derived from a 2-hour OGTT: implications for research studies. Diabetologia 50:2516-2525, 2007.

Utzschneider KM*, Tong J*, Montgomery B, Udayasankar J, Gerchman F, Marcovina SM, Watson CE, Ligueros-Saylan MA, Foley JE, Holst JJ, Deacon CF, Kahn SE: The dipeptidyl peptidase-4 inhibitor vildagliptin improves insulin sensitivity and ß-cell function in subjects with impaired fasting glucose. Diabetes Care 31:108-13, 2007.   *equally contributed

Utzschneider KM, Prigeon RL, Faulenbach MV, Tong J, Carr DB, Boyko EJ, Leonetti DL, McNeely MJ, Fujimoto WY, Kahn SE: An oral disposition index predicts the development of future diabetes above and beyond fasting and 2-hour glucose levels. Diabetes Care 32:335-41, 2009.

Utzschneider KM and Kowdley KV: Hereditary hemochromatosis and diabetes mellitus: implications for clinical practice. Nature Reviews Endocrinology 6:26-33, 2010.

Utzschneider, KM, van de Lagemaat A, Faulenbach M, Goedecke JH, Carr DB, Boyko EJ,  Fujimoto WY, Kahn SE: Similar adverse metabolic profile in lean and obese insulin resistant subjects with a first degree relative with type 2 diabetes. Obesity (Silver Spring) 18:1781-7, 2010.

Marina AL, Utzschneider KM, Wright LA, Montgomery BK, Marcovina SM, Kahn SE: Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and β-cell function. Diabetes Care 2012, 35(5):1119-25.

Utzschneider KM, Bayer-Carter JL, Arbuckle MD, Tidwell JM, Richards TL and Craft S: Beneficial effect of a weight stable, low fat/low saturated fat/low glycemic index diet to reduce liver fat in older subjects. British Journal of Nutrition, 2013, 109(6):1096-1104.

Smits M, Ioannou G, Boyko EJ and Utzschneider KM: Non-Alcoholic Fatty Liver Disease as an Independent Manifestation of the Metabolic Syndrome: Results of a U.S. National Survey in Three Ethnic Groups J Gastro and Hepatology, 2013, 28(4):664-670.


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