Kristina Utzschneider, M.D.
Metabolism, Endocrinology and Nutrition
Assistant Professor of Medicine
Dr. Utzschneider's research focuses on the interaction between liver disease and glucose metabolism. One study investigates the effect of iron overload due to hereditary hemochromatosis on insulin sensitivity and beta-cell function. A second study attempts to better understand the mechanisms linking non-alcoholic fatty liver disease and insulin resistance. In addition, she continues to study the relationship between measures of insulin response and insulin sensitivity using measures derived from an oral glucose tolerance test.
Utzschneider KM, Carr DB, Barsness SM, Kahn SE and Schwartz RS: Diet-induced weight loss is associated with an improvement in ß-cell function in older men. J Clin Endocrinol Metab 89:2704-2710, 2004.
Utzschneider KM, Carr DB, Hull RL, Kodama K, Shofer JB, Retzlaff BM, Knopp RH and Kahn SE: Impact of intra-abdominal fat and age on insulin sensitivity and ß-cell function. Diabetes 53:2867-2872, 2004.
Carr DB, Utzschneider KM, Boyko EJ, Asberry PJ, Hull RL, Kodama K, Callahan HS, Matthys CC, Leonetti DL, Schwartz RS, Kahn SE and Fujimoto WY: A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not ß-cell function. Diabetes 54:340-347, 2005.
Utzschneider KM, Carr DB, Tong J, Wallace TM, Hull RL, Zraika S, Xiao Q, Mistry JS, Retzlaff BM, Knopp RH and Kahn SE: Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologica, accepted for publication 2005.
Kahn SE, Hull RL, Utzschneider KM: Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-6, 2006.
van Genugten RE, Utzschneider KM, Tong J, Gerchman F, Zraika S, Udayasankar J, Boyko EJ, Fujimoto WY, Kahn SE, American Diabetes Association GENNID Study Group: Effects of sex and hormone replacement therapy use on the prevalence of isolated impaired fasting glucose and isolated impaired glucose tolerance in subjects with a family history of type 2 diabetes. Diabetes 55:3529-35, 2006.
Utzschneider KM, Kahn SE: Review: The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 91:4753-61, 2006.
Utzschneider KM, Prigeon RL, Carr DB, Hull RL, Tong J, Shofer JB, Retzlaff BM, Knopp RH, Kahn SE: Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses.
Diabetes Care 29:356-62, 2006
Wallace TM*, Utzschneider KM*, Tong J*, Carr DB, Hull RL, Zraika S, Bankson DD, Knopp RH, Kahn SE: Relationship of liver function tests to insulin sensitivity and intra-abdominal fat. Diabetes Care 30:2673-2678, 2007. *equally contributed
Utzschneider KM, Prigeon RL, Tong J, Gerchman F, Carr DB, Zraika S, Udayasankar J, Montgomery B, Mari A, Kahn SE: Within subject variability of measures of β-cell function derived from a 2-hour OGTT: implications for research studies. Diabetologia 50:2516-2525, 2007.
Utzschneider KM*, Tong J*, Montgomery B, Udayasankar J, Gerchman F, Marcovina SM, Watson CE, Ligueros-Saylan MA, Foley JE, Holst JJ, Deacon CF, Kahn SE: The dipeptidyl peptidase-4 inhibitor vildagliptin improves insulin sensitivity and ß-cell function in subjects with impaired fasting glucose. Diabetes Care 31:108-13, 2007. *equally contributed
Utzschneider KM, Prigeon RL, Faulenbach MV, Tong J, Carr DB, Boyko EJ, Leonetti DL, McNeely MJ, Fujimoto WY, Kahn SE: An oral disposition index predicts the development of future diabetes above and beyond fasting and 2-hour glucose levels. Diabetes Care 2008 [epub ahead of print].