Mara Y. Roth, M.D.
Metabolism, Endocrinology and Nutrition
Assistant Professor of Medicine
Mechanisms for control of intratesticular steroidogenesis and the effects of gonadotropins and exogenous hormones on gonadal function. Major physiological and clinical questions being addressed include: 1) Why do hormonal contraceptives work for some men, but not others? 2) What are the minimal intratesticular hormones required for spermatogenesis? 3) Can intratesticular steroid concentrations predict male infertility and be used to develop specific therapies?
Roth MY, Amory JK, Page ST: Treatment of male infertility secondary to morbid obesity. Nat Clin Prac Endo Metab 4:415-419, 2008.
Roth MY, Lin K, Amory JK, Matsumoto AM, Anawalt BD, Snyder CN, Kalhorn TF, Bremner WJ, Page ST: Serum LH correlates highly with intra-testicular steroid hormones in normal men. J Andrology 31:138-145, 2010.
Roth MY, Page ST, Lin K, Anawalt BD, Matsumoto AM, Snyder CN, Marck BT, Bremner WJ, Amory JK: Dose-dependent increase in intratesticular testosterone by very low dose human chorionic gonadotropin in normal men with experimental gonadotropin deficiency. J Clin Endo Metab 95:3806-3813, 2010.
Roth MY and Amory JK: Pharmacologic Development of male contraception. Clin Pharmacol Therapeutics 89:133-136, 2011.
Roth MY, Page ST, Lin K, Anawalt BD, Matsumoto AM, Snyder CN, Marck BT, Bremner WJ, Amory JK: The effect of gonadotropin withdrawal and stimulation with human chorionic gonadotropin on intratesticular androstenedione and DHEA in normal men. J Clin Endo Metab, accepted January 10, 2011.
Roth MY and Page ST: A role for DHT treatment in older men? Asian J Andrology. Advanced online publication January 10, 2011.