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Marcovina SMM-pic

Santica Marcovina, Ph.D., D.Sc.

Metabolism, Endocrinology and Nutrition

Research Professor of Medicine
Director, Northwest Lipid Metabolism and Diabetes Research Laboratories


Focus

Structure, metabolism and ethnic differences of lipoprotein(a) or Lp(a). Role of elevated L(a) levels and apo(a) isoform size in coronary artery disease and thrombosis. Clinical studies on diabetes prevention and intervention.


Publications

Marcovina SM, Albers JJ, Wijsman E, Zhang Z-H, Chapman NH, Kennedy H:  Differences in Lp(a) concentrations and apo(a) polymorphs between Black and White Americans. J Lipid Res 37:2569-2585, 1996.

Mooser V, Scheer D, Marcovina SM, Wang J, Guerra R, Cohen J, Hobbs HH:  The apo(a) gene is a major determinant of variation in plasma Lp(a) levels in African-Americans. Am J Hum Genet 61:402-417, 1997.

Sanan DA, Newland DL, Tao R, Marcovina S, Wang J, Mooser V, Hammer RE, Hobbs HH. Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet:  No accentuation by apolipoprotein(a). Proc Natl Acad Sci USA 95:4544-4549, 1998.

Marcovina SM and Koschinsky ML:  Lipoprotein(a) concentration and apolipoprotein(a) size:  a synergistic role in advanced atherosclerosis? Circulation 100:1151-1153, 1999.

Fan J, Challah M, Shimoyamada H, Shiomi M, Marcovina S, Watanabe T:  Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein(a). J Lipid Res 41:1004-1012, 2000.

Becker L, McLeod RS, Marcovina SM, Yao Z, Koschinsky ML:  Identification of a critical lysine residue in apo lipoprotein B-100 that mediates noncovalent interaction with apolipoprotein(a). J Biol Chem 276:36155-36162, 2001.

Longenecker JC, Klag MJ, Marcovina SM, Powe NR, Fink NE, Giaculli F, Coresh J:  Small apolipoprotein(a) size predicts mortality in end-stage renal disease:  the CHOICE study. Circulation 106:2812-2818, 2002.

Hancock MA, Boffa MB, Marcovina SM, Nesheim ME, Koschinsky ML:  Inhibition of plasminogen activation by lipoprotein(a):  critical domains in apolipoprotein(a) and mechanism of inhibition on fibrin and degraded fibrin surfaces. J Biol Chem 278:23260-23269, 2003.

Pellegrino M, Furmaniak-Kazmierczak E, LeBlanc JC, Cho T, Cao K, Marcovina SM, Boffa MB, Côté GP, Koschinksy ML:  The apolipoprotein(a) component of lipoprotein(a) stimulates actin stress fiber formation and loss of cell-cell contact in cultured endothelial cells. J Biol Chem 279:6526-6533, 2004.

Guerra R, Yu Z, Marcovina S, Peshock R, Cohen J, Hobbs HH:  Lipoprotein(a) and apolipoprotein(a) isoforms:  no association with coronary artery calcification in the Dallas Heart Study. Circulation 111:1471-1479, 2005.

Chretien J-P, Coresh J, Berthier-Schaad Y, Kao WHL, Fink NE, Klag MJ, Marcovina SM, Giaculli F, Smith MW:  Three single nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans.  J Med Genet 43:917-923, 2006.

Kitajima S, Jin Y, Koike T, Yu Y, Liu E, Shiomi M, Marcovina SM, Morimoto M, Watanabe T, Fan J:  Lp(a) enhances atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits. Atherosclerosis 193:269-276, 2007.

Albers JJ, Marcovina SM, Imperatore G, Snively BM, Stafford J, Fujimoto WY, Mayer-Davis EJ, Petitti DB, Pihoker C, Dolan L, Dabelea DM:  Prevalence and determinants of elevated apolipoprotein B and dense LDL in youth with type 1 and 2 diabetes:  the SEARCH for Diabetes in Youth study. J Clin Endocrinol Metab 93:735-742, 2008.

Erqou S, Kaptoge S, Perry PL, Di Angelantonio E, Thompson A, White IR, Marcovina SM, Collins R, Thompson SG, Danesh J:  Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular Mortality – The Emerging Risk Factors Collaboration. JAMA 302(4):412-423, 2009.

Winnicki M, Somers VK, Marcovina SM, Puato M, Phillips B, Zambon A, Pauletto P:  Leptin is associated with the Size of the Apolipoprotein(a) Particle in African Tribal Populations Living on Fish or Vegetarian Diet. Atherosclerosis 211:303-307, 2010.

Lamon-Fava S, Marcovina SM, Albers JJ, Kennedy H, DeLuca C, White CC, Cupples LA, McNamara JR, Seman LJ, Wilson PW, Schaefer EJ:  Lipoprotein(a) levels, apolipoprotein(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study.  J Lipid Res 52(6):1181-1187, 2011.  PMCID:  PMC3090239.