Savitha Subramanian, M.D.
Metabolism, Endocrinology and Nutrition
Assistant Professor of Medicine
Our research focuses on studying the role of inflammation in adipose tissue in obesity using mouse models, such as the LDL receptor deficient mouse, a model of the metabolic syndrome. Using this model we study the impact of components of the metabolic syndrome such as visceral obesity, insulin resistance and inflammation on atherosclerotic cardiovascular disease. We are currently also using this mouse model to study the effects of fat accumulation in the liver (nonalcoholic steatohepatitis) and the role of hepatic inflammation in insulin resistance and cardiovascular disease. A second area of interest is the role of the nutrient sensor molecule mTOR in adipose tissue in obesity. mTOR is important in longevity, a condition associated with improved insulin sensitivity. I am currently involved in studying the role of inhibiting mTOR using mouse models and dietary interventions to study the role of this complex molecule in obesity and insulin resistance.
I am actively involved in clinical care in the Endocrine, Diabetes and Lipid Clinics. My special
interests include areas of the thyroid, providing comprehensive care to diabetics, and management of complex lipid disorders including diabetic dyslipidemia.
Medical Specialties Clinic, UWMC
Diabetes Care Center at UW Roosevelt
Harborview Lipid and Nutrition Clinic
UW Medicine South Lake Union
Subramanian S, DeRosa M, Bernal-Mizrachi C, Laffely N, Cade WT, Yarasheski K, Cryer PE, Semenkovich CF: PPARα activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans. Am J Physiol Endocrinol Metab 291(6):E1365-71, 2006.
Han CY, Subramanian S, Chan CK, Omer M, Chiba T, Wight T, Chait A: Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 56(9):2260-73, 2007.
Subramanian S, Han CY, Chiba TC, McMillen T, Wang SA, Haw A, O’Brien KD, Chait A. Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 28(4):685-91, 2008.
Subramanian S, Chait A. The effect of dietary cholesterol on macrophage accumulation in adipose tissue: implications for the artery wall. Curr Opin Lipidol 20(1):39-44, 2009.
Yoon JS*, Subramanian S*, Wang SA, Goodspeed L, Sullivan B, Kim J, O’Brien KD, Chait A. Chronic insulin therapy alters adipose tissue inflammation in obese LDL receptor-deficient mice. Diabetologia 2011 May ;54(5):1252-60. Epub 2011 Feb 17. * Co-first author.
Subramanian S*, Goodspeed L, Wang SA, Yeh MM, Kowdley KV, O’Brien KD, Chait A. Dietary cholesterol recapitulates the NASH phenotype in obese LDL receptor-deficient mice. J Lipid Res. 2011 Sep;52(9):1626-35. * Corresponding author.
Subramanian S, Chait A. Hypertriglyceridemia secondary to obesity and diabetes. Biochim Biophys Acta 2011, inpress.