Stephanie Page, M.D., Ph.D.
Metabolism, Endocrinology and Nutrition
Professor of Medicine
Section Chief, Endocrinology and Diabetes, Harborview Medical Center
Physiologic and therapeutic properties of androgens and androgen manipulation in humans. Major projects include: 1) examination of the consequences of testosterone replacement on prostate health in middle-aged and elderly, hypogonaldal men at both the clinical, hormonal, and molecular levels; 2) examining the effect of androgens on host immunity and inflammation; and 3) determining the effect of testosterone on cardiovascular risk and risk factors. Continued involvement in projects investigating the pharmokinetics of novel oral formulations of testosterone delivery and the development of an effective, reversible male hormonal contraceptive.
Page ST, Herbst KL, Amory JK, Coviello AD, Anawalt BD, Matsumoto AM, Bremner WJ: Testosterone administration suppresses adiponectin levels in men. J Androl 26:85-92, 2005.
Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL: Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 90:1502-1510, 2005.
Page ST, Plymate SR, Bremner WJ, Matsumoto AM, Hess DL, Lin DW, Amory JK, Nelson PS, Wu JD: Effect of medical castration on CD4+ CD25+ T cells, CD8+T-cell IFN-γ expression, and NK cells: A physiological role of testosterone and/or its metabolites. Am J Physiol Endocrinol Metab 2005 Dec 13; [Epub ahead of print].
Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB: Low SHBG, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in non-obese men. J Clin Endocrinol Metab 2006 Jan 4 [Epub ahead of print].
Page ST, Amory JK, Anawalt BD, Irwig MS, Brockenbrough AT, Matsumoto AM, Bremner WJ: Testosterone gel combined with depomedroxyprogesterone acetate is an effective male hormonal contraceptive regimen and is not enhanced by the addition of a GnRH antagonist. J Clin Endocrinol Metab 91:4374-4380, 2006.
Amory JK, Page ST, Bremner WJ: Drug insight: Recent advances in male hormonal contraception. Nat Clin Pract Endocrinol Metab 2:32-41, 2006.
Page ST, Kupelian V, Bremner WJ, McKinlay JB: The androgen receptor gene CAG repeat polymorphism does not predict increased risk of heart disease: Longitudinal results from the Massachusetts Male Ageing Study. Clin Endocrinol 65:333-339, 2006.
Page ST, Lin DW, Mostaghel EA, Hess DL, True LD, Amory JK, Nelson PS, Matsumoto AM, Bremner WJ: Persistent intraprostatic androgen concentrations after medical castration in healthy men. J Clin Endocrinol Metab 91:3850-3856, 2006.
Page ST, Matsumoto AM, Bremner WJ: DHEA and tesosterone in the elderly. N Engl J Med 356:635, 2007.