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William J. Bremner, M.D., Ph.D.

Metabolism, Endocrinology and Nutrition

Department of Medicine Chair
Robert G. Petersdorf Professor of Medicine


Focus

Mechanisms for central nervous system control of pituitary gonadotropin secretion and the effects of gonadotropins on gonadal function. Major physiological and clinical questions being addressed include: (1) Can a safe, effective, reversible contraceptive for men be developed? (2) What are the effects of aging on the male reproductive endocrine system? (3) What are the effects of androgens in men and women? (4) What are the relative roles of LH and FSH in controlling testicular function?


Publications

Page ST, BA Mohr, CL Link, AB O’Donnell, WJ Bremner, JB McKinlay. Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging Study. Asian J Androl. 10:193-200, 2008.

Page ST, WJ Bremner, RV Clark, MA Bush, H Zhi, RB Caricofe, PM Smith, JK Amory. Nanomilled oral testosterone plus dutasteride effectively normalizes serum testosterone in normal men with induced Hypogonadism. J Androl. 29:222-227, 2008.

Amory JK, AD Coviello, ST Page, BD Anawalt, AM Matsumoto, WJ Bremner. Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropin. Fertil Steril. 89:380-386, 2008.

Liu PY, Swerdloff RS, Anawalt BD, Anderson RA, Bremner WJ, Elliesen J, Gu YQ, Kersemaekers WM, McLachlan RI, Meriggiola MC, Nieschlag E, Sitruk-Ware R, Vogelsong K, Wang XH, Wu FC, Zitzmann M, Handelsman DJ, Wang C. Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis. J Clin Endocrinol Metab. 93:1774-1783, 2008.

Amory JK, BD Anawalt, AM Matsumoto, ST Page, WJ Bremner, C Wang, RS Swerdloff, RV Clark. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men. J Urol. 179:2333-2338, 2008.

Roth MY, Lin K, Amory JK, Matsumoto AM, Anawalt BD, Snyder CN, KalhornTF, Bremner WJ, Page ST. Serum LH correlates highly with intratesticular steroid levels in normal men. J Androl. 31:138-145, 2010.

Bremner WJ. Testosterone deficiency and replacement in older men. N Engl J Med. 363:189-191, 2010.

Amory JK, Leonard TW, Page ST, O’Toole E, McKenna MJ, Bremner WJ. Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics. Cancer Chemother Pharmacol. 64:641-645, 2009.

Mahabadi V, Amory JK, Swerdloff RS, Bremner WJ, Page ST, Sitruk-Ware R, Christensen PD, Kumar N, Tsong YY, Blithe D, Wang C. Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men. J Clin Endocrinol Metab. 94:2313-2320, 2009.

Snyder CN, Clark RV, Caricofe RB, Bush MA, Roth MY, Page ST, Bremner WJ, Amory JK. Pharmacokinetics of 2 novel formulations of modified-release oral testosterone alone and with finasteride in normal men with experimental hypogonadism. J Androl. 31:527-535, 2010.

Roth MY, Page ST, Lin K, Anawalt BD, Matsumoto AM, Snyder CN, Marck BT, Bremner WJ, Amory JK. Dose-dependent increase in intratesticular testosterone by very low-dose human chorionic gonadotropin in normal men with experimental gonadotropin deficiency. J Clin Endocrinol Metab. 95:3806-3813, 2010.

Roth MY, Page ST, Lin K, Anawalt BD, Matsumoto AM, Marck B, Bremner WJ, Amory JK. The effect of gonadotropin withdrawal and stimulation with human chorionic gonadotropin on intratesticular androstenedione and DHEA in normal men.  J Clin Endocrinol Metab

Staiger TO, Wong EY, Schleyer AM, Martin DP, Levinson W, Bremner WJ. The role of quality improvement and patient safety in academic promotion: results of a survey of chairs of departments of internal medicine in North America. Am J Med. 124:277-80, 2011.

Lee A, Rubinow K, Clark RV, Caricofe RB, Bush MA, Zhi H, Roth MY, Page ST, Bremner WJ, Amory JK. Pharmacokinetics of Modified Slow-Release Oral Testosterone over Nine Days in Normal Men with Experimental Hypogonadism. J Androl.