EDUCATION AND TRAINING

M.D., University of Washington

Ph.D., Monash University, Melbourne, Australia (Physiology and Medicine)

Residency, University of Washington, Internal Medicine

Fellowship, University of Washington, Division of Metabolism and Endocrinology

OFFICE ADDRESS

University of Washington School of Medicine
1959 NE Pacific Street
UW Mailbox 356420
Seattle, WA 98195-6420


CURRENT RESEARCH INTERESTS

Mechanisms for central nervous system control of pituitary gonadotropin secretion and the effects of gonadotropins on gonadal function. Major physiological and clinical questions being addressed include:  (1) Can a safe, effective, reversible contraceptive for men be developed?  (2) What are the effects of aging on the male reproductive endocrine system?  (3) What are the effects of androgens in men and women?  (4) What are the relative roles of LH and FSH in controlling testicular function?


REPRESENTATIVE PUBLICATIONS

Cummings DE, Kumar N, Bardin CW, Sundaram K and Bremner WJ:  Prostate-sparing effects in primates of the potent androgen MENT:  A potential alternative to testosterone for androgen replacement and male contraception.  J Clin Endocrinol Metab 83:4212-4219, 1998.

Bagatell CJ and Bremner WJ:  The effects of aging and testosterone on lipids and cardiovascular risk.  J Clin Endocrinol Metab 83:3440-3441, 1998.

Zhang G-Y, Gu Y-Q, Wang X-H, Cui Y-G, and Bremner WJ:  A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men.  J Clin Endocrinol Metab 84:3642-3647, 1999.

Anawalt BD, Herbst KL, Matsumoto AM, Mulders TMT, Coelingh-Bennick HJT, and Bremner WJ:   Desogestrel plus testosterone effectively suppresses spermatogenesis but also causes modest weight gain and high-density lipoprotein suppression.  Fertil Steril 74:707-714, 2000.

Amory JK, Anawalt BD, Paulsen CA, and Bremner WJ:  Klinefelter's syndrome.  Lancet 356:333-335, 2000.

Amory JK and Bremner WJ:  Newer agents for hormonal contraception in the male.  Trends Endocrinol Metab 11:61-66, 2000.

Herbst KL, Coviello AD, Page S, Amory JK, Anawalt BD, Bremner WJ:  A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men.  J Clin Endocrinol Metab 89:5959-5965, 2004.

Gu YQ, Tong JS, Ma DZ, Wang XH, Yuan D, Tang WH, Bremner WJ:  Male hormonal contraception:  Effects of injections of testosterone undecanoate and depot medroxyprogesterone acetate at eight-week intervals in Chinese men.  J Clin Endocrinol Metab 89:2254-2262, 2004.

Matsumoto AM, Bremner WJ:  Serum testosterone assays--accuracy matters.  J Clin Endocrinol Metab 89:520-524, 2004.

Amory JK, Watts NB, Easley KA, Sutton PR, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL:  Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone.  J Clin Endocrinol Metab 89:503-510, 2004.

Matthiesson KL, Amory JK, Berger R, Ugoni A, McLachlan RI, Bremner WJ:  Novel male hormonal contraceptive combinations:  The hormonal and spermatogenic effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist.  J Clin Endocrinol Metab 90:91-97, 2005.

Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL:  Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T.  J Clin Endocrinol Metab 90:1502-1510, 2005.

Amory JK, Bremner WJ:  Oral testosterone in oil plus dutasteride in men:  A pharmacokinetic study.  J Clin Endocrinol Metab 90:2610-2617, 2005.