EDUCATION AND TRAINING

M.D., University of Washington School of Medicine, Seattle, WA

Internship, University of Southern California, Los Angeles, CA

Residency, University of Washington, Department of Medicine, Seattle, WA

Fellowship, University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Seattle, WA

John D. Brunzell, M.D.
Professor Emeritus of Medicine
Division of Metabolism, Endocrinology and Nutrition

OFFICE ADDRESS

University of Washington School of Medicine
1959 NE Pacific Street
UW Mailbox 356426
Seattle, WA 98195-6426


CURRENT RESEARCH INTERESTS

Genetic abnormalities in lipoprotein metabolism. Specific interest in: (1) the pathophysiological and molecular defects in familial combined hyperlipidemia; (2) the role of hepatic lipase gene and activity in determination of dyslipidemia seen in the metabolic syndrome with intraabdominal obesity and insulin resistance in diabetes and at menopause.


REPRESENTATIVE PUBLICATIONS

Purnell JQ, Hokanson JE, Marcovina SM, Cleary PA, Steffes MW, and Brunzell JD:  Effect of excessive weight gain with intensive therapy of type 1 diabetes on lipid levels and blood pressure.  JAMA 280:140-146, 1998.

Zambon A, Hokanson JE, Brown BG, and Brunzell JD:  Evidence for a new pathophysiological mechanism for coronary artery disease regression:  Hepatic lipase mediated changes in LDL density.  Circulation 99:1959-1964, 1999.

Carr MC, Hokanson JE, Deeb SS, Purnell JQ, Mitchell ES, and Brunzell JD:  A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intraabdominal fat in women.  Arterioscler Thromb Vasc Biol 19:2701-2707, 1999.

Brunzell JD and Deeb SS:  Familial lipoprotein lipase deficiency, apo CII deficiency and hepatic lipase deficiency.  In The Metabolic and Molecular Basis of Inherited Disease, 8th edition (CR Sciver, AI Beaudet, WS Sly, and D Vale, eds.) New York: McGraw-Hill Book Co, Chapter 117, pp 2789-2816, 2000.

Purnell JQ, Kahn SE, Schwartz RS, and Brunzell JD:  Relationship of insulin sensitivity and apolipoprotein B levels to intraabdominal fat in subjects with familial combined hyperlipidemia.  Arterioscler Thromb Vasc Biol 21:567-572, 2001.

Carr MC, Hokanson JE, Zambon A, Deeb SS, Barrett PH, Purnell JQ, and Brunzell JD:  The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity.  J Clin Endocrinol Metab 86:2831-2837, 2001.

Peterson J, Ayyobi AF, Ma Y, Henderson H, Reina M, Deeb SS, Santamarina-Fojo S, Hayden MR, Brunzell JD:  Structural and functional consequences of missense mutations in Exon 5 of the lipoprotein lipase gene.  J Lipid Res 43:398-406, 2002.

Carr MC, Ayyobi AF, Murdoch SJ, Deeb SS, Brunzell JD:  Contribution of hepatic lipase, lipoprotein lipase and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women.  Arterioscler Thromb Vasc Biol 22:667-673, 2002.

Purnell JQ, Dev RK, Steffes MW, Cleary PA, Palmer JP, Hirsch IB, Hokanson JE, Brunzell JD:  Hypoglycemia, familial DM, and weight gain.  Diabetes 52:2623-2629, 2003.

Cheung MC, Sibley SD, Palmer JP, Oram JF, Brunzell JD:  Lipoprotein lipase and hepatic lipase:  Their relationship with HDL subspecies Lp(A-I) and Lp(A-I,A-II).  J Lipid Res 44:1552-1558, 2003.

Sibley SD, Palmer JP, Hirsch IB, Brunzell JD:  Visceral obesity, hepatic lipase activity, and dyslipidemia in type 1 diabetes.  J Clin Endocrinol Metab 88:3379-3384, 2003.

Purnell JQ, Dev RK, Steffes MW, Cleary PA, Palmer JP, Hirsch IB, Jokanson JE, Brunzell JD:  Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the Diabetes Control and Complications Trial.  Diabetes 52:2623-2629, 2003.

Carr MC and Brunzell JD:  Abdominal obesity and dyslipidemia in the metabolic syndrome:  Importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk.  J Clin Endocrinol Metab 89:2601-2607, 2004.

Brunzell JD:  Increased apo B in small dense LDL particles predicts premature coronary artery disease.  Arterioscler Thromb Vasc Biol 25:474-475, 2005.

Zambon A, Brown BG, Deeb SS, Brunzell JD:  Genetics of apolipoprotein B and apolipoprotein AI and premature coronary artery disease.  J Intern Med 259:473-480, 2006.

Zambon A, Brown BG, Hokanson JE, Motulsky AG, Brunzell JD:  Genetically determined apo B levels and peak LDL density predict angiographic response to intensive lipid-lowering therapy.  J Intern Med 259:401-409, 2006.

Sibley SD, de Boer IH, Steffes MW, Brunzell JD; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Study Group:  Intra-abdominal fat and elevated urine albumin excretion in men with type 1 diabetes.  Diabetes Care 30:1898-1900, 2007.

de Boer IH, Sibley SD, Kestenbaum B, Sampson JN, Young B, Cleary PA, Steffes MW, Weiss NS, Brunzell JD; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group:  Central obesity, incident microalbuminuria, and change in creatinine clearance in the epidemiology of diabetes interventions and complications study.  J Am Soc Nephrol 18:235-243, 2007.

Murdoch SJ, Boright AP, Paterson AD, Zinman B, Steffes M, Cleary P, Edwards K, Marcovina SS, Purnell JQ, Brunzell JD; the DCCT/EDIC Research Group:  LDL composition in E2/2 subjects and LDL distribution by Apo E genotype in type 1 diabetes.  Atherosclerosis 192:138-147, 2007.

Brunzell JD:  Hypertriglyceridemia.  New Engl J Med 2007, in press.