EDUCATION AND TRAINING

Fellowship, University of Washington, Department of Pathology, Seattle, WA

Ph.D., Massachusetts Institute of Technology, Applied Biological Sciences, Boston, MA

OFFICE ADDRESS

University of Washington School of Medicine
1959 NE Pacific Street
UW Mailbox 356426
Seattle, WA 98195-6426


CURRENT RESEARCH INTERESTS

Ongoing research focuses on atherosclerosis with an emphasis on defining the mechanisms and consequences of lipoprotein retention in the arterial wall.  Of interest are (i) understanding the nature of the interactions between lipoproteins and extracellular matrix molecules, and (ii) understanding the regulatory mechanisms by which lipoproteins modulate the synthesis of extracellular matrix molecules by both macrophages and smooth muscle cells.  These studies emphasize a role for factors associated with diabetes, including hyperglycemia and lipoprotein oxidation, in the development of vascular disease.

REPRESENTATIVE PUBLICATIONS

Chang MY, Sasahara M, Chait A, Raines EW, and Ross R: Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol.   II. Cellular composition and proliferation. Arterioscler Thromb Vasc Biol 15:1631-1640, 1995.

Chang MY, Olin KL, Tsoi C, Wight TN, and Chait A:  Human monocyte-derived macrophages secrete two forms of proteoglycan-macrophage colony stimulating factor (PG-MCSF) that differ in their ability to bind low density lipoproteins.  J Biol Chem 273:15985-15992, 1998.

Chang MY, Potter-Perigo S, Tsoi C, Chait A, and Wight TN: Oxidized low density lipoproteins regulate synthesis of monkey aortic smooth muscle cell proteoglycans that have enhanced native low density lipoprotein-binding properties.  J Biol Chem 275:4766-4773, 2000.

Chang MY, Potter-Perigo S, Wight TN, and Chait A:  Oxidized low density lipoproteins bind to non-proteoglycan components of smooth muscle extracellular matrices.  J Lipid Res 42:824-833, 2001.

Chang MY, Tsoi C, Wight TN, Chait A:  Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor.  Arterioscler Thromb Vasc Biol 23:809-815, 2003.

Chang MY, Han CY, Wight TN, Chait A:  Antioxidants inhibit the ability of lysophosphatidylcholine to regulate proteoglycan synthesis. Arterioscler Thromb Vasc Biol 26(3):494-500, 2006.