EDUCATION AND TRAINING

Ph.D., State University of New York at Buffalo, Biochemistry

University of Washington, Department of Medicine

OFFICE ADDRESS

Northwest Lipid Metabolism and Diabetes Research Laboratories
401 Queen Anne Avenue North
UW Mailbox 357333
Seattle, WA 98109


CURRENT RESEARCH INTERESTS

Metabolic pathways and physiological functions of high density lipoprotein (HDL) particles. Studies of the structure and metabolic functions of phospholipid transfer protein. Identify and characterize new HDL-associated proteins, and their roles in lipid metabolism and other physiological functions.


REPRESENTATIVE PUBLICATIONS

Cheung MC, Brown BG, Wolf AC and Albers JJ: Altered particle size distribution of apolipoprotein A-I-containing lipoproteins in subjects with coronary artery disease. J Lipid Res 32:383-394, 1991.

Cheung MC, Wolf AC, Knopp RH, and Foster DM:  Protein transfer between A-I-containing lipoprotein subpopulations:  evidence of non-transferable A-I in particles with A-II.   Biochim Biophys Acta 1165:68-77, 1992.

Cheung MC, Mendez AJ, Wolf AC, and Knopp RH: Characterization of apolipoprotein A-I and A-II-containing lipoproteins in a new case of HDL deficiency resembling Tangier disease and their effects on intracellular efflux. J Clin Invest 91:522-529, 1993.

Cheung MC, Lichtenstein AH, and Schaefer EJ:  Effects of a diet restricted in saturated fatty acids and cholesterol on the composition of apolipoprotein A-I-containing lipoprotein particles in the fasting and fed states.  Am J Clin Nutr 60:911-918, 1994.

Cheung MC, Wolfbauer G, and Albers JJ:  Plasma phospholipid mass transfer rate:   Relationship to plasma phospholipid and cholesteryl ester transfer activities and lipid parameters.  Biochim Biophys Acta 1303:103-110, 1996.

Cheung MC, Walden CE, and Knopp RH:  Comparison of the effects of triphasic oral contraceptives with desogestrel or levonorgestrel on Apo A-I-containing HDL particles.   Metabolism 48:658-664, 1999.

Cheung MC, Zhao X-Q, Chait A, Albers JJ, and Brown BG:  Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL.  Arterioscler Thromb Vasc Biol 21:1320-1326, 2001.

Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ:  Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease.  N Engl J Med 345:1583-1592, 2001.

Cheung MC, Knopp RH, Retzlaff B, Kennedy H, Wolfbauer G, and Albers JJ:  Association of plasma phospholipid transfer protein activity with IDL and buoyant LDL:  Impact of gender and adiposity.  Biochim Biophys Acta 1587:53-59, 2002.

Brown BG, Cheung MC, Lee AC, Zhao XQ, Chait A:  Antioxidant vitamins and lipid therapy:  End of a long romance?  Arterioscler Thromb Vasc Biol 22:1535-1546, 2002.

Cheung MC, Sibley SD, Palmer JP, Oram JF, Brunzell JD:  Lipoprotein lipase and hepatic lipase:  Their relationship with HDL subspecies Lp(A-I) and Lp(A-1,A-II).  J Lipid Res 44:1552-1558, 2003.

Albers JJ, Cheung MC:  Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism.  Curr Opin Lipidol 15:255-260, 2004.

Tu AY, Cheung MC, Zhu X, Knopp RH, Albers JJ:  Low-density lipoprotein inhibits secretion of phospholipid transfer protein in human trophoblastic BeWo cells.  Exp Biol Med 229:1046-1052, 2004.

Vuletic S, Peskind ER, Marcovina SM, Quinn JF, Cheung MC, Kennedy H, Kaye JA, Jin LW, Albers JJ:  Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro.  J Neurosci Res 80:406-413, 2005.

Knopp RH, Paramsothy P, Retzlaff BM, Fish B, Walden C, Dowdy A, Tsunehara C, Aikawa K, Cheung MC:  Gender differences in lipoprotein metabolism and dietary response:  Basis in hormonal differences and implications for cardiovascular disease.  Curr Atheroscler Rep 7(6):472-479, 2005.

Cheung MC, Brown BG, Marino Larsen EK, Frutkin AD, O'Brien KD, Albers JJ:  Phospholipid transfer protein activity is associated with inflammatory markers in patients with cardiovascular disease.  Biochim Biophys Acta 1762(1):131-137, 2006.

Cheung MC, Albers JJ:  Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins.  J Lipid Res 47(6):1315-1321, 2006.

Vaisar T, Pennathur S, Green PS, Gharib SA, Hoofnagle AN, Cheung MC, Byun J, Vuletic S, Kassim S, Singh P, Chea H, Knopp RH, Brunzell J, Geary R, Chait A, Zhao XQ, Elkon K, Marcovina S, Ridker P, Oram JF, Heinecke JW:  Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.  J Clin Invest 117(3):746-756, 2007.