EDUCATION AND TRAINING

M.D., Johns Hopkins University School of Medicine, Baltimore

Residency, Presbyterian Hospital, Columbia-Presbyterian Medical Center, New York, and University of Washington School of Medicine

Clinical Associate, National Institute of Arthritis and Metabolic Diseases, Section on Human Biochemical Genetics, National Institutes of Health, Bethesda

Fellowship, University of Washington, Division of Metabolism and Endocrinology

OFFICE ADDRESS

University of Washington School of Medicine
1959 NE Pacific Street
UW Mailbox 356426
Seattle, WA 98195-6426


CURRENT RESEARCH INTERESTS

Etiologic factors for type 2 diabetes mellitus and cardiovascular disease and their pathogenesis are being examined in a migrant, pure Japanese-American population in Seattle.  We are especially interested in risk factors associated with the development of central obesity (visceral obesity) and the insulin resistance syndrome.  Genetic markers related to type 2 diabetes, obesity, and the insulin resistance syndrome are being searched for in Japanese-American families.  We are also collaborating with investigators in Japan and in Brazil.


REPRESENTATIVE PUBLICATIONS

Boyko EJ, Leonetti DL, Bergstrom RW, Newell-Morris L, and Fujimoto WY:  Low insulin secretion and high fasting insulin and C-peptide levels predict increased visceral adiposity:  5-year follow-up among initially nondiabetic Japanese-American men.   Diabetes 45:1010-1015, 1996.

McNeely MJ, Boyko EJ, Weigle DS, Shofer JB, Chessler SD, Leonetti DL, and Fujimoto WY:  Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans.  Diabetes Care 22:65-70, 1999.

Fujimoto WY, Bergstrom RW, Boyko EJ, Chen KW, Leonetti DJ, Newell-Morris L, Shofer JB, and Wahl PW:  Visceral adiposity and incident coronary heart disease in Japanese-American men:  The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study.  Diabetes Care 22:1808-1812, 1999.

Tsai EC, Boyko EJ, Leonetti DL, and Fujimoto WY: Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men.  Internat J Obes 24:485-491, 2000.

Boyko EJ, Fujimoto WY, Leonetti DL, and Newell-Morris L:  Visceral adiposity and risk of type 2 diabetes mellitus:  A prospective study among Japanese Americans.  Diabetes Care 23:465-471, 2000.

Liao D, Shofer JB, Boyko EJ, McNeely MJ, Leonetti DL, Kahn SE, and Fujimoto WY:  Abnormal glucose tolerance and increased risk for cardiovascular disease in Japanese Americans with normal fasting glucose.  Diabetes Care 24:39-44, 2001.

McNeely MJ, Boyko EJ, Shofer JB, Newell-Morris L, Leonetti DL, Fujimoto WY:  Standard definitions of overweight and central adiposity for determining diabetes risk in Japanese Americans.  Am J Clin Nutr 74:101-107, 2001.

Jensen CC, Cnop M, Hull RL, Fujimoto WY, and Kahn SE:  ß-cell function is a major contributor to oral glucose tolerance in high risk relatives of four ethnic groups in the United States.  Diabetes 51:2170-2178, 2002.

Nemoto M, Sasaki T, Deeb SS, Fujimoto WY, and Tajima N:  Differential effect of PPARgamma2 variants in the development of type 2 diabetes between native Japanese and Japanese Americans.  Diab Res Clin Pract 57:131-137, 2002.

Liao D, Asberry PJ, Shofer JB, Callahan H, Matthys C, Boyko EJ, Leonetti D, Kahn SE, Austin M, Newell L, Schwartz RS, and Fujimoto WY:  Improvement of body mass index, body composition, and body fat distribution with lifestyle modification in Japanese Americans with impaired glucose tolerance.  Diabetes Care 25:1504-1510, 2002.

Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE, Fujimoto WY:  Visceral adiposity and the risk of impaired glucose tolerance:  A prospective study among Japanese Americans.  Diabetes Care 26:650-655, 2003.

McNeely MJ, Boyko EJ, Leonetti DL, Kahn SE, Fujimoto WY:  Comparison of a clinical model, the oral glucose tolerance test, and fasting glucose for prediction of type 2 diabetes risk in Japanese Americans.  Diabetes Care 26:758-763, 2003.

Austin MA, Edwards KL, McNeely MJ, Chandler WL, Leonetti DL, Talmud PJ, Humphries SE, Fujimoto WY:  Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese Americans.  Diabetes 53:1166-1169, 2004.

Tsai EC, Matsumoto AM, Fujimoto WY, Boyko EJ:  Association of bioavailable, free, and total testosterone with insulin resistance:  Influence of sex hormone-binding globulin and body fat.  Diabetes Care 27:861-868, 2004.

Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE, Fujimoto WY:  Visceral adiposity is an independent predictor of incident hypertension in Japanese Americans.  Ann Intern Med 140:992-1000, 2004.

Carr DB, Utzschneider KM, Boyko EJ, Asberry PJ, Hull RL, Kodama K, Callahan HS, Matthys CC, Leonetti DL, Schwartz RS, Kahn SE, Fujimoto WY:  A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function.  Diabetes 54:340-347, 2005.

Tong J, Fujimoto WY, Kahn SE, Weigle DS, McNeely MJ, Leonetti DL, Shofer JB, Boyko EJ:  Insulin, C-peptide, and leptin concentrations predict increased visceral adiposity at 5- and 10-year follow-ups in nondiabetic Japanese Americans.  Diabetes 54:985-990, 2005.

Carr DB, Utzschneider KM, Hull RL, Tong J, Wallace TM, Kodama K, Shofer JB, Heckbert SR, Boyko EJ, Fujimoto WY, Kahn SE:  Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes.  Diabetes Care 29:2078-2083, 2006. 

Fujimoto WY, Jablonski KA, Bray GA, Kriska A, Barrett-Connor E, Haffner S, Hanson R, Hill JO, Hubbard V, Stamm E, Pi-Sunyer FX, Diabetes Prevention Program Research Group:  Body size and shape changes and the risk of diabetes in the diabetes prevention program. Diabetes 56:1680-1685, 2007.

Kovac IP, Havlik RJ, Foley D, Peila R, Hernandez D, Wavrant-De Vrieze F, Singleton A, Egan J, Taub D, Rodriguez B, Masaki K, Curb JD, Fujimoto WY, Wilson AF:  Linkage and association analyses of type 2 diabetes/impaired glucose metabolism and adiponectin serum levels in Japanese Americans from Hawaii.  Diabetes 56:537-540, 2007. 

Gerchman F, Tong J, Utzschneider KM, Hull RL, Zraika S, Udayasankar J, McNeely MJ, Andress DL, Leonetti DL, Boyko EJ, Fujimoto WY, Kahn SE:  Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans. Diabetes Res Clin Pract 77:320-326, 2007.