EDUCATION AND TRAINING

MD, Duke University, Durham NC

PhD, Duke University, Department of Pathology, Durham NC

Residency, University of Washington, Department of Medicine, Seattle WA

Fellowship, University of Washington, Division of Metabolism, Endocrinology and Nutrition, Seattle, WA

OFFICE ADDRESS

University of Washington School of Medicine
1959 NE Pacific Street
UW Mailbox 357710
Seattle, WA 98195-7710


CURRENT RESEARCH INTERESTS

My research focuses on the pathogenesis and treatment of type 1 diabetes. Specific interests include: 1) the role of autoantibodies in the disease process of type 1 diabetes, and the significance of particular antibody specificities in better defining clinical phenotype and disease outcome; 2) the role of genetic vs. environmental factors in the disease pathogenesis of children who present with mixed features of type 1 and type 2 diabetes; 3) mechanisms resulting in loss of the counterregulatory glucagon response to hypoglycemia in type 1 diabetes subjects, hypothesized to be autoimmune in etiology; and 4) relationship between oxidative stress and glycemic variability in type 1 diabetes patients.


REPRESENTATIVE PUBLICATIONS

Gilliam LK, Binder KA, Banga JP, Madec A-M, Ortqvist E, Kockum I, Daniels TL, Luo D, and Hampe CS:  Multiplicity of the antibody response to GAD65 in type 1 diabetes.  Clin Exp Immunol 138:337-41, 2004.

Schlosser M, Banga JP, Madec A-M, Binder KA, Strebelow M, Rjasanowski I, Gilliam LK, Luo D, and Hampe CS:  Dynamic changes of GAD65Ab epitope specificities during progression to type 1 diabetes. Diabetologia 48:922-30, 2005.

Gilliam LK, Brooks-Worrell BM, Palmer JP, Greenbaum CJ, Pihoker C:  Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetes.  J Autoimmun 25:244-50, 2005.

Gilliam LK, Palmer JP:  How useful is autoantibody screening in adult-onset diabetes?  Nat Clin Pract Endocrinol Metab 2:490-1, 2006.

Gilliam LK, Kohn AD, Lalani T, Swanson PE, Vasko V, Patel A, Livingston RB, Pickett CA:  Capecitabine therapy for refractory metastatic thyroid carcinoma: a case series.  Thyroid 16:801-10, 2006. 

Gilliam LK, Jensen RA, Yang P, Weigle DS, Greenbaum CJ, Pihoker C:  Evaluation of leptin levels in subjects at risk for type 1 diabetes.  J Autoimmun 26:133-7, 2006.

Gilliam LK and Palmer JP:  LADA.  Insulin 1:122-27, 2006.

Jensen RA, Gilliam LK, Torn C, Landin-Olsson M, Karlsson FA, Palmer JP, Kockum I, Akesson K, Lernmark B, Lynch K, Breslow N, Lernmark A:  Multiple factors affect the loss of measurable C-peptide over six years in newly diagnosed 15-35 year old diabetic subjects.  J Diab Compl 2007, in press.

Jensen R, Gilliam L, Torn C, Landin-Olsson M, Palmer J, Akesson K, Kockum I, Lernmark B, Karlsson AF, Lynch K, Breslow N, Lernmark A, Sundkvist G on behalf of the Diabetes Incidence Study in Sweden Group:  Islet cell antibody levels after the diagnosis of young adult diabetic patients.  Diab Med, 2007, in press.

Gilliam LK, Liese AD, Bloch CA, Davis C, Snively BM, Curb D, Williams DE, Pihoker C:  Diabetes family history, autoimmunity and cardiovascular risk factors in children with diabetes in the SEARCH for Diabetes in Youth Study.  Ped Diab, 2007, in press.