EDUCATION AND TRAINING

M.D., University of Uppsala, Sweden

University of Uppsala, Sweden, Medical Chemistry

OFFICE ADDRESS

University of Washington School of Medicine
1959 NE Pacific
UW Mailbox 357370
Seattle, WA 98195-7370


CURRENT RESEARCH INTERESTS

Biosynthesis and structural roles of membrane-associated, polyunsaturated phosphoglycerides.  Factors that influence the interaction of cytosolic proteins with cell membranes.  Role of phosphatidic acid in cell signaling.  Roles of prenylated protein.


REPRESENTATIVE PUBLICATIONS

Higgs HN and Glomset JA:  Purification and properties of a phosphatidic acid-preferring phospholipase A1 from bovine testis:  Examination of the molecular basis of its activation.  J Biol Chem 271:10874-10883, 1996.

Park JA, Farnsworth CC and Glomset JA:  Ca²⁺/Calmodulin causes rab3A to dissociate from synaptosomal membranes J Biol Chem 272:20857-20865, 1997.

Hollenback D and Glomset JA:  On the relation between a stearoyl-specific transacylase from bovine testis membranes and a co-purifying acyltransferase.   Biochemistry 37:363-376, 1997.

Higgs HN, Han MH, Johnson GE and Glomset JA:  Cloning of a phosphatidic acid-preferring phospholipase A1 from bovine testis.  J Biol Chem 273:5468-5477, 1998.

Thomas W and Glomset JA:  Multiple factors influence the binding of a soluble, Ca²⁺-independent, diacylglycerol kinase to unilamellar phosphoglyceride vesicles.  Biochemistry 38:3310-3319, 1999.

Thomas W and Glomset JA:  Affinity purification and catalytic properties of a soluble, Ca²⁺-independent diacylglycerol kinase.  Biochemistry 38:3320-3326, 1999.

Coppola T, Perret-Menoud V, Luthi S, Farnsworth CC, Glomset JA, and Regazzi R:  Disruption of Rab3A-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis.  EMBO J 18:5585-5891, 1999.

Glomset JA:  Protein-lipid interactions on the surface of cell membranes.  Curr Opin Struct Biol 9:425-427, 1999.

Lin Q, Higgs HN, and Glomset JA:  Membrane lipids have multiple effects on interfacial catalysis by a phosphatidic acid-preferring phospholipase A1 from bovine testis.  Biochemistry 39:9335-9344, 2000.

Han MH, Han DKM, Aebersold RH, and Glomset JA:  Effects of protein kinase CK2, extracellular signal-related kinase 2, and protein phosphatase 2A on a phosphatidic acid-preferring phospholipase A1.  J Biol Chem (in press), 2001.