EDUCATION AND TRAINING
M.D., University of Missouri, Columbia, MO
Residency, Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL
Fellowship, Washington University School of Medicine, Metabolism and Endocrinology
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Irl B. Hirsch, M.D.
Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
OFFICE ADDRESS
University of Washington School of Medicine
1959 NE Pacific
UW Mailbox 354691
Seattle, WA 98195-4691
CURRENT RESEARCH INTERESTS
Using new technologies to improve diabetes therapy, particularly
with the use of real-time continuous glucose sensors. I am also
interested in the use of insulin for in-patient diabetes, and the non-glycemic
effects of insulin, particularly its anti-inflammatory actions.
I have recently focused on the role of glycemic variability in the
pathogenesis of diabetes-related complications.
REPRESENTATIVE PUBLICATIONS
Tsai EC, Hirsch IB, Brunzell JD, Chait A: Reduced plasma peroxyl radical trapping capacity and increased susceptibility
of LDL to oxidation in poorly controlled IDDM. Diabetes
43:1010-1014, 1994.
Hirsch IB, Goldberg HI, Ellsworth A, Evans TC, Herter CD, Ramsey SD, Mullen M, Neighbor WE, Cheadle
AD: A multifaceted intervention in support of diabetes treatment guidelines: a cont
trial. Diabetes Res Clin Pract 58:27-36, 2002.
Hirsch IB: In-patient hyperglycemia--are we ready to treat it yet?
J Clin Endocrinol Metab 87:975-977, 2002.
Hirsch IB: The death of the "1800 Calorie ADA
Diet". Clin Diabetes 20:51-52, 2002.
Trence DL, Kelly JL, Hirsch IB: The rationale and management of hyperglycemia for in-patients with
cardiovascular disease: time for change. J Clin Endocrinol Metab
88:2430-2437, 2003.
DeWitt DE, Hirsch IB: Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific
review. JAMA 289:2254-2264, 2003.
Hirsch IB: Insulin analogues. N Engl J Med 352:174-183, 2005.
Brownlee M, Hirsch IB: Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic
complications. JAMA 295:1707-1708, 2006.
Hirsch IB: Arguments against the use of inhaled insulin. Diabetes Technol
Ther 1:S111-S114, 2007.
Hirsch IB: TZDs--Where do we go from here? DOC News,
August 2007.
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