EDUCATION AND TRAINING
Med.Dr., University of Umeå, Umeå, Sweden
University of Chicago, Department of Biochemistry
University of Umeå, Department of Histology
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Åke Lernmark, Ph.D.
R.H. Williams Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
OFFICE ADDRESS
University of Washington School of Medicine
1959 NE Pacific Street
UW Mailbox 357710
Seattle, WA 98195-7710
CURRENT RESEARCH INTERESTS
Etiology and pathogenesis of type 1 diabetes, molecular genetics of
islet autoimmunity and the molecular mechanisms of insulin secretion.
The research interest is focused at understanding: 1) the mechanisms
of the autoimmune reaction to specific beta cell proteins such as
glutamic acid decarboxylase, which predicts and precedes the clinical
onset of type 1 diabetes, 2) identification and positional cloning of
genetic factors that increase the risk for type 1 diabetes and 3)
clinical trials to test whether immune tolerance induction prevent
type 1 diabetes.
REPRESENTATIVE PUBLICATIONS
Lernmark A, Agardh CD: Immunomodulation
with human recombinant autoantigens. Trends Immunol 26:608-612,
2005.
Fuller JM, Kwitek AE, Hawkins TJ, Moralejo DH, Lu W, Tupling TD,
Macmurray AJ, Borchardt G, Hasinoff M, Lernmark A: Introgression
of F344 rat genomic DNA on BB rat chromosome 4 generates
diabetes-resistant lymphopenic BB rats. Diabetes 55:3351-3357,
2006.
Roach JC, Deutsch K, Li S, Siegel AF, Bekris LM, Einhaus DC, Sheridan
CM, Glusman G, Hood L, Lernmark A, Janer M, Swedish Childhood Diabetes
Study Group and Diabetes Incidence in Sweden Study Group:
Genetic mapping at 3-kilobase resolution reveals inositol
1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in
Sweden. Am J Hum Genet 79:614-627, 2006.
Bekris LM, Jensen RA,
Lagerquist E, Hall TR, Agardh CD, Cilio CM, Lethagen AL, Lernmark A,
Robertson JA, Hampe CS: GAD65 autoantibody epitopes in
adult patients with latent autoimmune diabetes following GAD65
vaccination. Diabet Med 24:521-526, 2007.
Jensen RA, Gilliam LK, Torn C, Landin-Olsson M, Karlsson FA, Palmer
JP, Kockum I, Akesson K, Lernmark B, Lynch K, Breslow N, Lernmark A
and Diabetes Incidence Study in Sweden (DISS) Group: Multiple
factors affect the loss of measurable C-peptide over 6 years in newly
diagnosed 15- to 35-year-old diabetic subjects. J Diabetes
Complications 21:205-213, 2007.
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