EDUCATION AND TRAINING

Ph.D., Sc.D., University of Urbino, Italy, and University of Pavia, Italy

OFFICE ADDRESS

Northwest Lipid Metabolism and Diabetes Research Laboratories
401 Queen Anne Avenue North
UW Mailbox 357333
Seattle, WA 98109


CURRENT RESEARCH INTERESTS

Structure, metabolism and ethnic differences of lipoprotein(a) or Lp(a).  Role of elevated L(a) levels and apo(a) isoform size in coronary artery disease and thrombosis.  Clinical studies on diabetes prevention and intervention.


REPRESENTATIVE PUBLICATIONS

Sun H, Unoki H, Wang X, Liang J, Ichikawa T, Arai Y, Shiomi M, Marcovina SM, Watanabe T, Fan J: Lipoprotein(a) enhances advanced atherosclerosis in WHHL transgenic rabbits expressing human apolipoprotein(a). J Biol Chem 277:47486-47492, 2002.

Hancock MA, Boffa MB, Marcovina SM, Nesheim ME, Koschinsky ML: Inhibition of plasminogen activation by lipoprotein(a): critical domains in apolipoprotein(a) and mechanism of inhibition on fibrin and degraded fibrin surfaces. J Biol Chem 278:23260-9, 2003.

Pellegrino M, Furmaniak-Kazmierczak E, LeBlanc JC, Cho T, Cao K, Marcovina SM, Boffa MB, Côté GP, Koschinksy ML: The apolipoprotein(a) component of lipoprotein(a) stimulates actin stress fiber formation and loss of cell-cell contact in cultured endothelial cells. J Biol Chem 279:6526-33, 2004.

Sharp RH, Perugini MA, Marcovina SM, McCormick SPA: Structural features of apolipoprotein B synthetic peptides that inhibit lipoprotein(a) assembly. J Lipid Res 45:2227-2234, 2004.

Haffner S, Temprosa M, Crandall J, Fowler S, Goldberg R, Horton E, Marcovina SM, Mather K, Orchard T, Ratner R, Barrett-Connor E for the Diabetes Prevention Program Research Group: Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance. Diabetes 54:1566-1572, 2005.

Guerra R, Yu Z, Marcovina SM, Peshock R, Cohen J, Hobbs HH: Lipoprotein(a) and apolipoprotein(a) isoforms: no association with coronary artery calcification in the Dallas Heart Study. Circulation 111:1471-1479, 2005.

Schneider M, Witztum JL, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE: High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res. 46:769-778, 2005.

Chretien J-P, Coresh J, Berthier-Schaad Y, Kao WHL, Fink NE, Klag MJ, Marcovina SM, Giaculli F, Smith MW: Three single nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans. J Med Genet 43:917-923, 2006.

Marcovina SM, Crea F, Davignon J, Kaski JC, Koenig W, Landmesser U, Pieri PL, Schulz-Menger J, Shaw LJ, Sobesky J: Biochemical and bioimaging markers for risk assessment and diagnosis in major cardiovascular diseases: a road to integration of complementary diagnostic tools. J Int Med 261:214-234, 2007.

Kitajima S, Jin Y, Koike T, Yu Y, Liu E, Shiomi M, Marcovina SM, Morimoto M, Watanabe T, Fan J: Lp(a) enhances atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits. Atherosclerosis 2007, in press.