EDUCATION AND TRAINING
M.D., Harvard Medical School, Boston, MA (magna cum laude)
Residency, Columbia-Presbyterian Medical Center, New York
Fellowship, National Institute of Child Health and Human Development, Endocrinology and
Reproduction Research Branch and Developmental Endocrinology Branch, Bethesda, MD
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George R. Merriam, M.D.
Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
Deputy Associate Chief of Staff for Research,
Research Service, VA Puget Sound Health Care System
OFFICE ADDRESS
VA Puget Sound Health Care System (151)
American Lake Division
UW Mailbox 358282
Tacoma, WA 98493
CURRENT RESEARCH INTERESTS
Neuroendocrine regulation of pituitary function, with emphasis on CNS control of
growth hormone and gonadotropin secretion. The focus is on three areas of study: (1) the
physiology of growth hormone-releasing hormone (GHRH) and GH-releasing peptides, the
neurotransmitter interactions which regulate GH secretion, and the therapeutic role of
GHRH in GH deficiency and aging; (2) the central regulation of female reproductive
function, including the pathophysiology of disorders such as hypothalamic and lactational
amenorrhea, hyperprolactinemia, late luteal phase dysphoric disorder, and luteal phase
deficiency; and (3) the role of GH and growth factors in modulating ovarian function.
REPRESENTATIVE PUBLICATIONS
Merriam GR and Wachter KW: Algorithms for the study of episodic hormone secretion. Am J
Physiology 243:E310-E318, 1982.
Gelato MC, Rittmaster R, Pescovitz O, D’Agata R, Nixon W, Loriaux DL, and Merriam
GR: Effects of pulsatile administration of growth hormone-releasing hormone on short-term
linear growth in children with growth hormone deficiency. J Clin Endocrinol Metab
61:444-450, 1985.
Pfeiffer DG, MacLusky NJ, Barnea E, Naftolin F, Krey LC, Loriaux DL, and Merriam GR:
Are catechol estrogens obligatory mediators of estrogen action in the CNS? I.
Characterizatio of pharmacological probes with different receptor binding affinities and
catechol estrogen formation rates. J Endocrinol 110:489-497, 1986.
Schmidt PJ, Nieman LK, Grover GN, Muller KL, Merriam GR, and Rubinow DR: Lack of effect
of induced menses on symptoms in women with premenstrual syndrome. N Engl J Med
324:1174-1179, 1991.
Batista MC, Cartledge TP, Zellmer A, Nieman LK, Merriam GR, and Loriaux DL: Evidence
for a critical role of progesterone in the regulation of the midcycle gonadotropin surge
and ovulation. J Clin Endocrinol Metab 74:565-570, 1992.
Chik CL, Almeida OFX, Libre EA, Booth JD, Renquist D, and Merriam GR:
Photoperiod-driven changes in reproductive function in male rhesus monkeys. J Clin
Endocrinol Metab 74:1068-1074, 1992.
Dunaif A, Givens J, Haseltine F, and Merriam GR (eds.) Polycystic Ovary Syndrome.
Boston, Blackwell Scientific Publications, 1992.
Cassorla F, Mericq V, Garcia H, Cristiano AM, Avila A, Boric A, Iñiguez G, and Merriam
GR: The effects of b 1-adrenergic blockade on the growth
response to growth hormone-releasing hormone therapy in growth hormone deficient children.
J Clin Endocrinol Metab 80:2997-3001, 1995.
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