EDUCATION AND TRAINING

M.D., University of Chicago Medical School (with honors)

Residency, VA Hospital and UC San Francisco Moffet Hospital, San Francisco, CA

Fellowship, USPHS, Cardiovascular Research Institute, University of California Medical Center, San Francisco, CA; University of Washington, Division of Endocrinology

OFFICE ADDRESS

VA San Diego Health Care System (111G)
3350 La Jolla Village Drive
San Diego, CA 92161

CURRENT RESEARCH INTERESTS

Pathogenesis of non-insulin dependent diabetes mellitus.  Elucidation of the role of the islet b-cell in the development and maintenance of hyperglycemia in humans.  Physiology and pathophysiology of amylin secretion in vivo in human and animal models in vivo and in vitro.  Pathogenesis of the neurological complications of diabetes mellitus and the potential role of aldose reductase inhibitors to ameliorate or prevent them in man.  Regulation of body adiposity and control of food intake by neuropeptides and their potential role in development of obesity.   Mechanisms of neuropeptide regulation of metabolic events, including the effect of peripheral signals such as insulin and leptin to regulate NPY and CCK biosynthesis and secretion by neural cells.


REPRESENTATIVE PUBLICATIONS

Porte D Jr and Kahn SE:  ß-cell dysfunction and failure in type 2 diabetes:  potential mechanisms.  Diabetes 50:S160-S163, 2001.

Porte D Jr:  Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications.  Diabetes Metab Res Rev 17:181-188, 2001.

Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH and Kahn R:  Thiazolidinedione use, fluid retention, and congestive heart failure:  a consensus statement from the American Heart Association and American Diabetes Association.  Diabetes Care 27:256-263, 2004.

Schwartz MW, Porte D Jr:  Diabetes, obesity, and the brain.  Science 307:375-9, 2005.

Porte D Jr, Baskin DG, Schwartz MW:  Insulin signaling in the central nervous system:  a critical role in metabolic homeostasis and disease from C. elegans to humans.  Diabetes 54:1264-76, 2005.

Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJ, American Heart Association, American Diabetes Association:  Primary prevention of cardiovascular diseases in people with diabetes mellitus:  a scientific statement from the American Heart Association and the American Diabetes Association.  Circulation 115:114-26, 2007.