EDUCATION AND TRAINING

M.D., University of Zagreb, Croatia

Fellowship, University of Washington, Division of Metabolism, Endocrinology and Nutrition, Seattle, WA

OFFICE ADDRESS

Northwest Lipid Metabolism and Diabetes Research Laboratories
401 Queen Anne Avenue North
UW Mailbox 357333
Seattle, WA 98109


CURRENT RESEARCH INTERESTS

The role of lipid transfer proteins in the brain.  Lipid and lipoprotein metabolism in health and disease.  Biomarkers of neurodegeneration.  Pathophysiology of Alzheimer's disease, multiple sclerosis and other neurological disorders.


REPRESENTATIVE PUBLICATIONS

Vuletic S, Jin LW, Marcovina SM, Peskind ER, Moller T, Albers JJ:  Widespread distribution of phospholipid transfer protein (PLTP) in human central nervous system: Evidence for PLTP synthesis by glia and neurons and for increased levels in Alzheimer's disease.  J Lipid Res 44:1113-1123, 2003.

O'Brien KD, Vuletic S, McDonald TO, Wolfbauer G, Lewis K, Tu A-Y, Marcovina SM, Wight TN, Chait A, Albers JJ:  Cell-associated and extracellular phospholipid transfer protein (PLTP) in human coronary atherosclerosis.  Circulation 108:270-274, 2003.

Vuletic S, Peskind ER, Marcovina SM, Quinn JF, Cheung MC, Kennedy H, Kaye JA, Jin L-W, Albers JJ:  Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases:  PLTP induces apo E secretion in primary human astrocytes in vitro.  J Neurosci Res 80:406-413, 2005.

Vuletic S, Riekse RG, Marcovina SM, Peskind ER, Hazzard WB, Albers JJ:  Statins of different brain penetrability differentially affect CSF PLTP activity.  Dem Geriatr Cogn Disord 22:392-398, 2006.

Riekse RG, Li G, Petrie EC, Leverenz JB, Vavrek D, Vuletic S, Albers JJ, Montine TJ, Lee VM, Lee M, Seubert P, Galasko D, Schellenberg GD, Hazzard WR, Peskind ER:  Effect of statins on Alzherimer's disease biomarkers in cerebrospinal fluid.  J Alzheimers Dis 10:399-406, 2006.

Vaisar T, Pennathur S, Green PS, Gharib SA, Hoofnagle AN, Cheung MC, Byun J, Vuletic S, Kassim S, Singh P, Chea H, Knopp RH, Brunzell J, Geary R, Chait A, Zhao XQ, Elkon K, Marcovina SM, Ridker P, Oram JF, Heinecke JW:  Shotgun proteomics implicates protease inhibition and complement activation in the anti-inflammatory properties of HDL.  J Clin Invest, 2007, in press.