EDUCATION AND TRAINING

M.D., Harvard Medical School

Residency, University of Chicago Hospitals and Clinics, Department of Medicine

Fellowship, University of Washington, Division of Metabolism, Endocrinology and Nutrition

OFFICE ADDRESS

Harborview Medical Center
325 Ninth Avenue
UW Mailbox 359757
Seattle, WA 98104-2499


CURRENT RESEARCH INTERESTS

Studies of mechanisms of experimental and human obesity. Identification of factors produced by adipose tissue that influence appetite and fuel metabolism.  Effect of dietary macronutrient composition and aging on body fat mass.  Alteration in body fat distribution by protease inhibitor therapy in HIV infection.  Undergraduate physiology education.


REPRESENTATIVE PUBLICATIONS

Yukawa M, McCormick WC, Rajan S, Matsumoto AM, Wallace JI, Perlman RA, Weigle DS:  Leptin levels are appropriate for body mass index in older men who experience involuntary weight loss.  J Am Geriatr Soc 50:1566-1571, 2002.

 Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ:  Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.  N Engl J Med 346:1623-1630, 2002.

Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS:  Elevated plasma ghrelin levels in Prader-Willi syndrome.  Nature Med 8:643-644, 2002.

Martin IP, Breen PA, Weigle DS:  Absence of hypersensitivity to glucocorticoids in antiretroviral-associated lipodystrophy.  Obes Res 11:21-24, 2003.

Weigle DS, Cummings DE, Newby PD, Breen PA, Frayo RS, Matthys CC, Callahan HS, Purnell JQ:  Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet.  J Clin Endocrinol Metab 88:1577-1586, 2003.

Weigle DS:  Pharmacological therapy of obesity:  Past, present, and future.  J Clin Endocrinol Metab 88:2462-2469, 2003.

Callahan HS, Cummings DE, Pepe MS, Breen PA, Matthys CC, Weigle DS:  Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans.  J Clin Endocrinol Metab 89:1319-1324, 2004.

Weigle DS, Breen PA, Matthys CC, Callahan HS, Meeuws KE, Burden VR, Purnell JQ:  A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations.  Am J Clin Nutr 82:41-48, 2005.

Koren MS, Purnell JQ, Breen PA, Matthys CC, Callahan HS, Weigle DS:  Plasma C-reactive protein concentration is not affected by isocaloric dietary fat reduction.  Nutrition 22:444-448, 2006.

Yukawa M, Cummings DE, Matthys CC, Callahan HS, Frayo RS, Spiekerman CF, Weigle DS:  Effect of aging on the response of ghrelin to acute weight loss.  J Am Geriatr Soc 54:648-653, 2006.

Purnell JQ, Cummings D, Weigle DS:  Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity.  Int J Obes 31:385-389, 2007.

Koren MS, Purnell JQ, Breen PA, Matthys CC, Callahan HS, Meeuws KE, Burden VR, Weigle DS:  Changes in plasma amino acid levels do not predict satiety and weight loss on diets with modified macronutrient composition.  Ann Nutr Metab 51:182-187, 2007.