EDUCATION AND TRAINING
Fellowship, University of Washington, Division of Metabolism,
Endocrinology and Nutrition, Seattle, WA
Fellowship, McGill University Hospital Centre, Division of
Endocrinology, Montreal, Quebec
Chief Resident, Royal Victoria Hospital, Division of Internal
Medicine, Montreal, Quebec
Residency, Royal Victoria Hospital, Division of Internal Medicine,
Montreal, Quebec
M.D., McGill University, Montreal, Quebec
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Brent Wisse, M.D.
Associate Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
OFFICE ADDRESS
University of Washington School of Medicine
325 Ninth Avenue
UW Mailbox 359757
Seattle, WA 98104-2499
CURRENT RESEARCH INTERESTS
The focus of the laboratory is on investigating the central (CNS)
mechanisms that lead to diminished appetite (anorexia) in chronic
disease states. Anorexia and weight loss are major complications
of many chronic diseases including cancer, AIDS, adrenal insufficiency
and inflammatory disorders, that lead to an excess morbidity and
mortality. The hypothalamic neuropeptides that control appetite
are being examined in a variety of rodent models of pathologic
anorexia, with particular emphasis on treatments that block
melanocortin and cytokine signaling. The long-term goals are to
identify targets that may lead to improved treatment of anorexia and
of obesity.
REPRESENTATIVE PUBLICATIONS
Wisse BE, Campfield LA, Marliss EB, Morais JA, Tenenbaum R, Gougeon
R: Effect of prolonged moderate and severe energy restriction
and refeeding on plasma leptin concentrations in obese women. Am
J Clin Nutr 70:321-330, 1999.
Wisse BE, Frayo RS, Schwartz MW, Cummings DE: Reversal of
cancer anorexia by blockade of central melanocortin receptors in
rats. Endocrinology 142:3293-3301, 2001.
Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle
DS: A preprandial rise in plasma ghrelin levels suggests a role
in meal initiation in humans. Diabetes 50:1714-1719, 2001.
Wisse BE, Schwartz MW: Role of melanocortins in control of
obesity. Lancet 358:857-859, 2001.
Wisse BE, Schwartz MW, Cummings DE: Melanocortin signaling and
anorexia in chronic disease states. Ann N Y Acad Sci
994:275-281, 2003.
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