We are conducting a search for an Assistant Professor in bacteriology. An ideal candidate will bring an innovative research program that synergizes with existing strengths of the department in the areas of bacterial pathogenesis, bacterial cell biology and/or microbial communities; however, all highly qualified individuals pursuing cutting-edge bacteriology research are encouraged to apply. Our department is a collegial, vibrant, interactive community of researchers who are committed to world-class science and training at all levels, including supporting the development of junior faculty. Located in Seattle, the department is part of an extensive network of research institutes and institutes of higher learning that offer a wealth of resources and opportunity for collaboration. All University of Washington faculty engage in teaching, research and service. The position is a full-time, tenure track position in the School of Medicine. Applicants should have a Ph.D., M.D., or foreign equivalent. For consideration, please submit a cover letter, curriculum vitae, research prospectus, reprints or preprints as a single PDF, a brief statement regarding your teaching experience and/or philosophy, and 3 confidential references via Interfolio (http://apply.interfolio.com/25379). Please note the Interfolio reference process requires you to request references through Interfolio and then return to Interfolio to apply those references to your application after your referee submits them. Applications received by October 24th, 2014 will be given priority review. University of Washington is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to, among other things, race, religion, color, national origin, sex, age, status as protected veterans, or status as qualified individuals with disabilities.
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October 21, 2014, 4:00 PM, S-060 Foege Hall (Genome Sciences)
Graham Walker, Ph.D.
American Cancer Society Professor
Howard Hughes Medical Institute Professor
Massachusetts Institute of Technology
"Getting Inside and Living There: Bacterial Functions for Symbiosis"
Our analyses of Sinorhizobium meliloti have offered insights into the molecular mechanisms underlying the symbiosis between legumes and this nitrogen-fixing bacterium, including the roles of plant-encoded antimicrobial peptides. This research has also led to unexpected findings including commonalities between this symbiosis and the chronic intracellular infections caused by the human pathogen Brucella, the discovery of the “missing step” in vitamin B12 biosynthesis, and the discovery of a new RNase that plays crucial roles in rRNA maturation, 70S ribosome quality control, and small RNA regulation.
October 28, 2014, 4:00 PM, S-060 Foege Hall (Genome Sciences)
Ralph Isberg, Ph.D.
Howard Hughes Medical Institute Professor
Tufts University School of Medicine Professor
"Microbial Community Behavior During Growth in Deep Tissue Sites."
After spread from the initial site of infection into deep tissues, invasive bacterial pathogens establish colonies that involve a battle with host innate immune functions. Analysis of bacteria in both animal models and in culture has demonstrated that survival in the presence of host immune cells requires that the bacteria encode virulence-associated proteins. In recent years, it has become clear that during growth within a host site, bacteria have heterogeneous transcriptions patterns. Therefore, the transcriptional profile of bacteria growing in tissues is merely the average of the whole population. The molecular basis for this heterogeneity is unclear, but has been hypothesized to be due to bacteria being in spatially distinct sites in tissue. We have investigated this issue by analyzing the growth of enteropathogenic Yersinia in deep tissue sites. We showed that within a single microcolony in tissues, there are at least three supopulations of bacteria that respond to distinct signals. Bacteria on the extreme periphery respond to cell attachment signals that upregulate transcripts in response to the attachment to neutrophils. A second population includes these bacteria as well as other peripheral nonattached bacteria that upregulate genes in response to soluble host-derived antimicrobial molecules. Bacteria in the center of the microcolony, on the other hand, are protected from both the cell contact signals as well as from the soluble host-derived molecules. Protection of the bacteria in the center of the microcolony from the antimicrobial action required the participation of bacteria on the periphery. These studies demonstrate that growth within tissues results in transcriptional specialization within a single focus of microbial replication, facilitating pathogen counterattack against the host response.