March 11, 2014, 4:00 PM, T-639 Health Sciences Building
Victor Torres, Ph.D.
Department of Microbiology
New York School of Medicine
"Bi-component leukotoxins control Staphylococcus aureus pathogenesis by coordinating immune evasion and nutrient acquisition”
Upon access to the bloodstream, Staphylococcus aureus has the potential to spread hematogenously to almost every body site resulting in myriad of serious infections. One potential virulence trait that endows this bacterium with the ability to thrive inside the human host is the production of an arsenal of pore-forming toxins. Among these toxins, S. aureus produces several leukotoxins, which target and injure the host leukocytes required for infection control. In this seminar, I will present an overview of our current understanding on how S. aureus leukotoxins contribute to the pathogenesis of this important microorganism.
March 18, 2014, 4:00 PM, T-639 Health Sciences Building
Alice Telesnitsky, Ph.D.
Department of Microbiology and immunology
University of Michigan Medical School
"Retroviral RNA: Have folds. Will travel."
Retroviruses' single primary transcript serves at least three replication functions: as mRNA, as substrate for splicing, and as genomic RNA. Isomerization of 5' leader RNA into alternate folds, which are trapped by protein associations, likely dictates RNA fate decisions. This talk will describe new insight into how alternate RNA folds and differences in their spatiotemporal formation impact retroviral viability and genetics, and other aspects of retroviral RNA.