We are conducting a search for an Assistant Professor in bacteriology. An ideal candidate will bring an innovative research program that synergizes with existing strengths of the department in the areas of bacterial pathogenesis, bacterial cell biology and/or microbial communities; however, all highly qualified individuals pursuing cutting-edge bacteriology research are encouraged to apply. Our department is a collegial, vibrant, interactive community of researchers who are committed to world-class science and training at all levels, including supporting the development of junior faculty. Located in Seattle, the department is part of an extensive network of research institutes and institutes of higher learning that offer a wealth of resources and opportunity for collaboration. All University of Washington faculty engage in teaching, research and service. The position is a full-time, tenure track position in the School of Medicine. Applicants should have a Ph.D., M.D., or foreign equivalent. For consideration, please submit a cover letter, curriculum vitae, research prospectus, reprints or preprints as a single PDF, a brief statement regarding your teaching experience and/or philosophy, and 3 confidential references via Interfolio (http://apply.interfolio.com/25379). Please note the Interfolio reference process requires you to request references through Interfolio and then return to Interfolio to apply those references to your application after your referee submits them. Applications received by October 24th, 2014 will be given priority review. University of Washington is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to, among other things, race, religion, color, national origin, sex, age, status as protected veterans, or status as qualified individuals with disabilities.
For questions about this position, please email firstname.lastname@example.org.
January 6, 2015, 4:00 PM, HSB T-639
Anthony DeFranco, Ph.D.
Department of Microbiology and Immunology
University of California San Francisco
"Contribution of TLRs in B cells to the germinal center response in health and disease"
Toll-like receptors (TLRs) have emerged as one of the most important families of innate immune receptors for initiating inflammation and also for promoting adaptive immune responses. While initial work suggested that TLR stimulation of B cells promotes an extrafollicular antibody response, which is responsible for rapid production of moderate affinity antibodies, we have found that TLR9 can strongly enhance the germinal center response, which produces high affinity class-switched antibody made by long-lived plasma cells. In particular, the B cell responds strongly to a combination of a particulate antigen with repetitive epitopes and the presence of a TLR9 or TLR7 ligand attached to the particle. B cells stimulated in this way rapidly outcompete B cells in germinal centers that cannot signal via their TLRs due to deletion of the signaling component MyD88. These B cells exhibit enhanced affinity maturation. In addition, B cells stimulated in this way enhance the response of follicular helper T cells. This pathway appears to be important not only for making high affinity antibodies against infecting viruses, but also in making the anti-nuclear antibodies that are characteristic of human lupus
January 13, 2015, 4:00 PM, HSB T-639
Justin Sonnenburg, Ph.D.
Department of Microbiology and Immunology
Stanford University, School of Medicine
"Deconstructing, engineering, and rewilding the intestinal microbiota"
The Sonnenburg lab investigates the principles that underlie microbial community function within the gut. Our overarching goal is to define the mechanisms that connect changes in the gut environment, such as dietary change or presence of a pathogen, to the microbiota’s response and impact on host biology. The lab applies molecular genetic and systems-level tools to intestinal microbiology and uses gnotobiotic mouse models to unravel the complexities of interactions that occur within the gastrointestinal tract. We are currently pursuing a deeper understanding of gut microbiota spatial organization using quantitative image analysis. New pursuits include leveraging synthetic biology to engineer gut symbionts that can record their own life experiences, detect inflammation, or execute site-specific therapeutic delivery. We are also working to better understand the factors that contribute to microbiota deterioration in the modern world, and how this deterioration may be reversed. The combined insights from these projects are helping us to explore the vast frontier of microbiota reprogramming, building upon recent success of fecal transplants.