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Jesse Bloom
Affiliate Assistant Professor in Microbiology
Assitant Member, Fred Hutchinson Cancer Research Center

Website
Email: jbloom@fhcrc.org
Phone: (206) 667-3622, (206) 667-3603
Office Location: Fred Hutchinson Cancer Research Center

 

 

 

 

 

Research:

Rapid evolution is a defining feature of many of the most medically problematic viral diseases, including influenza. Although this rapid evolution is usually bad from the perspective of public health, it offers a unique vantage from which to study a range of important questions in biology. For instance, consider the figure below, which summarizes the evolution of the human and swine descendants of the 1918 influenza pandemic. It took less than 90 years for these two viral lineages to become as different at the protein level as humans and pigs themselves and the full sequences of many of the evolutionary intermediates are known. Furthermore, this is just one example of the many viral evolutionary histories that can be reconstructed in remarkable detail.

Selected Publications:

Jesse D. Bloom, L. Ian Gong, and David Baltimore. "Permissive secondary mutations enable the evolution of influenza oseltamivir resistance." Science. 5983:1272-1275 (2010)


Jesse D. Bloom, Sy T. Labthavikul, Christopher R. Otey, and Frances H. Arnold. "Protein stability promotes evolvability." Proc. Natl. Acad. Sci. USA. 103:5869-5874 (2006)


Jesse D. Bloom and Matthew J. Glassman. "Inferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin." PLoS Comput. Biol. 5:e1000349 (2009)


Jesse D. Bloom, Alpan Raval, and Claus O. Wilke. "Thermodynamics of neutral protein evolution." Genetics. 175:255-266 (2007)


 



 

 



 

Department of Microbiology · University of Washington · Box 357735 · Seattle WA 98195-7735

phone: (206) 543-5824 · fax: (206) 543-8297 · micro@u.washington.edu