Research:
Dr. Corey obtained his M.D. from the University of Michigan. In addition to his affiliation with the Department of Microbiology, he is head of the Division of Virology within the Department of Laboratory Medicine and head of the Program in Infectious Diseases at the Fred Hutchinson Cancer Research Center.
Opportunities for research projects in herpesviruses (HSV, CMV, and HHV-8), HIV and Hepatitis C are available. Both laboratory-based studies of transitional research studies are available. Laboratory-based projects include studies of pathogenesis of T Cell immune responses to HSV among immunocompromised and immunocompetent patients, studies of CMV infection among bone marrow transplant patients and studies of the virology and immunology of Kaposi's sarcoma associated herpes virus. The HSV program is directed at defining the role HSV specific T cells play in viral reactivation and disease severity and a program to develop a T cell based HSV-2 vaccine is underway.
Selected Publications:
Hosken N, McGowan P, Meier A, Koelle DM, Sleath P, Wegener F, Elliott M, Grabstein K, Posavad C, Corey L. The diversity of the CD8+ T cell response to herpes simplex virus type 2 proteins among persons with genital herpes. J Virol 80:5509-5515
Wick WD, Yang OO, Corey L, Self SG. How many HIV-1 infected target cells can a cytotoxic T-lymphocyte kill? J Virol 2005; 79:13579-13586
Barcy S, Huang ML, Corey L, Koelle DM. Longitudinal analysis of herpes simplex-specific CD4+ T cell clonotypes in infected tissues and blood. J Infect Dis 2005 191:2012-21.
Liu H, Carrington M, Wang C, Holte S, Lee J, Greene B, Hladik F, Koelle DM, Wald A, Kurosawa K, Rinaldo CR, Celum C, Detels R, Corey L, McElrath MJ, Zhu T. Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbin nonintegrin-related molecule: effects on HIV-1 susceptibility. J Infect DIs 2006; 193:698-702.
Zhu J, Koelle DM, Cao J, Vazquez J, Huang ML, Hladik F, Wald A, Corey L. Immune surveillance by HSV-specific CD8+ T cells contiguous to sensory nerve endings in genital skin. J Exper Med (In press)
|
