Professor Emeritus of Microbiology
Office Location: HH-505
Campus Box: 359743
Dr. Coyle worked on the genetics of Neurospora crassa while obtaining her Ph.D. at Kansas State University. She did her postdoctoral work in repair mechanisms of the bacteriophage of Bacillus subtilis and in mammalian cells at the University of Chicago and also had a postdoctoral fellowship in public health and medical laboratory microbiology at Temple University School of Medicine in Philadelphia. Currently, in addition to holding faculty positions in the Departments of Microbiology and Laboratory Medicine, she is the director of clinical microbiology laboratories at Harborview Medical Center. She was section editor for the 4th edition of the Clinical Microbiology Manual for the American Society for Microbiology.
Dr. Coyle worked in Dr. Neal Groman's laboratory and studied the epidemiology of a diphtheria epidemic that had occurred in Seattle between 1972 and 1982. Analysis of DNA restriction fragments and patterns from DNA probe studies revealed different levels of genetic diversity that characterized each of the three biotypes of C. diphtheriae. Diversity also varied with the stage of the epidemic.
Dr. Coyle's laboratory recently has focused on taxonomic questions regarding new species of mycobacteria and coryneform organisms from clinical specimens. The laboratory was the first in this country to describe Mycobacterium genavense, a fastidious organism that causes sepsis in patients with AIDS. Collaboration with the molecular biologists in the Microbiology Department enables this laboratory to apply DNA technology to taxonomic issues as well as the epidemiology of clinically significant questions including infection control and antibiotic resistance in Gram positive organisms.
Springer, B., WK Wu, A et al, M. B. Coyle and E.C. Böttger. Isolation and characterization of a unique group of slowly growing mycobacteria: description of Mycobacterium lentiflavum sp. nov. J. Clin. Microbiol. 34:1100-1107. 1996.
Ritter, Deborah, La Donna C. Carlson, Barry K. Logan, L. Scott Ramos, James O. Kilburn, and Marie B. Coyle. Differentiation of Mycobacterium genavense and Mycobacterium simiae by automated mycolic acid analysis with high performance liquid chromatography. J. Clin. Microbiol. 34:2004-2006. 1996.
Dougherty, Molly J., David H. Spach, Ann M. Larson, Thomas M. Hooton, and Marie B. Coyle. Evaluation of an extended blood culture protocol to isolate fastidious organisms from patients with AIDS. J. Clin. Microbiol. 34:2444-2447. 1996.
Haas, W. H., R. Butler, P. Kirschner, B. B. Plikaytis, M. B. Coyle, B. Amthor, A. G. Steigerwalt, D. J. Brenner, M. Salfinger, J. T. Crawford, E. C. Bottger, and H. J. Bremer. A new agent of mycobacterial lymphadenitis in children: Mycobacterium heidelbergense sp. nov. J. Clin. Microbiol. 35:3203-3209. 1997.
LaDonna Carlson, Carolyn Wallis, and Marie B. Coyle. A standardized BACTEC method to measure clarithromycin susceptibility of Mycobacterium genavense. J. Clin. Microbiol. 36:748-751. 1998.