Professor of Microbiology
Office Location: Health Sciences K-451A
Campus Box: 357110
The Fang laboratory is interested in a broad range of questions relating to innate immunity and infections caused by Salmonella, Staphylococcus aureus and other pathogenic bacteria. In vitro studies are correlated with studies of bacterial survival in macrophages and virulence in normal or immunocompromised mice. Specific projects include the antimicrobial actions of nitric oxide, the role of alternative sigma factors and counter-silencing in virulence gene regulation, and the importance of iron metabolism in bacterial pathogenesis.
Richardson AR, Libby SJ, Fang FC. A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity. Science. 2008 Mar 21;319(5870):1672-6.
Navarre WW, Porwollik S, Wang Y, McClelland M, Rosen H, Libby SJ, Fang FC. Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella. Science. 2006 Jul 14;313(5784):236-8..
Fang FC. Sigma cascades in prokaryotic regulatory networks. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4933-4.
Fang FC. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol. 2004 Oct;2(10):820-32.
Stamler JS, Lamas S, Fang FC. Nitrosylation. the prototypic redox-based signaling mechanism. Cell. 2001 Sep 21;106(6):675-83.
Mastroeni P, Vazquez-Torres A, Fang FC, Xu Y, Khan S, Hormaeche CE, Dougan G. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. J Exp Med. 2000 Jul 17;192(2):237-48.
Vazquez-Torres A, Jones-Carson J, Mastroeni P, Ischiropoulos H, Fang FC. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro. J Exp Med. 2000 Jul 17;192(2):227-36.
Vazquez-Torres A, Xu Y, Jones-Carson J, Holden DW, Lucia SM, Dinauer MC, Mastroeni P, Fang FC. Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase. Science. 2000 Mar 3;287(5458):1655-8.
Vazquez-Torres A, Jones-Carson J, Bäumler AJ, Falkow S, Valdivia R, Brown W, Le M, Berggren R, Parks WT, Fang FC. Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature. 1999 Oct 21;401(6755):804-8.