Lucas "Luke" Hoffman, MD, PhD
Assistant Professor in Pediatrics, Seattle Children's Hospital
Adjunct Assistant Professor, UW Microbiology
Email: Lucas Hoffman
Office Location: Health Sciences K307
Campus Box: 356320
I am a clinician-scientist; clinically, I am a pediatric pulmonologist, focused on the health and disease of children’s lungs. One of the most vexing problems I face in this clinical role is how to treat chronic lung infections, particularly those suffered by people with cystic fibrosis (CF), chronic endobronchial tubes, and non-CF bronchiectasis. Because of my frustration with these infections, my laboratory efforts concentrate on how to better study and treat these devastating infections. My hope is to halt the lung diseases many chronic infections generate, and to improve the lung health of children worldwide.
Hoffman LR; D'Argenio DA; MacCoss MJ; Zhang Z; Jones RA; Miller SI; Aminoglycoside Antibiotics Induce Bacterial Biofilm Formation. Nature, 2005. 436(7054):1171-5.
Hoffman, LR; Déziel, E; D’Argenio, DA; Lépine, F; Emerson, J; McNamara, S; Gibson, RL; Ramsey, BW; Miller, SI. Selection for Staphylococcus aureus small-colony variants due to growth in the presence ofPseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA, 2006. 103(52):19890-5..
Hoffman, LR; Kulasekara, HD; Emerson, J; Houston, LS; Burns, JL; Ramsey, BW; and Miller, SI.Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression. J. Cyst. Fibros. 2009 Jan;8(1):66-70. Epub Oct., 2008.
Hoffman, LR; Richardson, AR; Houston, LS; Kulasekara, HD; Martens-Habbena, W; Klausen, M; Burns, JL; Stahl, DO; Hassett, D; Fang, F; and Miller, SI. Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway. PLoS Pathogens, 2010 Jan 8;6(1):e1000712.
Elliott, D; Burns, JL; and Hoffman, LR. Prevalence and clinical significance of tobramycin-mediated biofilm induction in Pseudomonas aeruginosa cystic fibrosis isolates: An exploratory study. Antimicrobial Agents and Chemotherapy, 2010;54(7):3024-6.
Stressman, FA; Rogers, GB; Daniels, TWV; Lilley, AK; Marsh, P; Carroll, MP; Hoffman, LR; Jones, G; Allen, CE; Patel, N; Forbes, B; Tuck, A; and Bruce, KD. Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation? Journal of Cystic Fibrosis, 2011;10(5) 357-365.